Statistical Analysis of Gene Expression Mechanism with Hierarchical Stochastic Model

层次随机模型基因表达机制的统计分析

• 批准号: 23700263
• 负责人: HASEGAWA Yoshihiko
• 金额: $ 1.66万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700263/
• 关键词: 生体生命情報学; 遺伝子; 生物物理; 遺伝子発現系; 遺伝子発現; 確率過程

In the present project, I investigated effects of temporally inhomogeneous noise on gene regulatory systems by using statistical methods and computational simulations. In order to perform the analysis, I developed an analytical approach and applied it to several biological models such as a bistable switch and a ratchet model. The developed method can calculate many statistical properties of systems driven by the temporally inhomogeneous noise. I also studied effects of structural inhomogeneity on the performance of genetic oscillators and showed that the existence of the period mismatch in a pair of coupled oscillators enhances entrainability, i.e. the ability to respond to external periodic stimuli.

在本项目中，我研究了时间非均匀噪声对基因调控系统的影响，通过使用统计方法和计算机模拟。为了进行分析，我开发了一种分析方法，并将其应用于几个生物模型，如一个开关和棘轮模型。所发展的方法可以计算由时间非均匀噪声驱动的系统的许多统计特性。我还研究了遗传振荡器的性能上的结构不均匀性的影响，并表明，在一对耦合振荡器的周期失配的存在下，增强可重复性，即响应外部周期性刺激的能力。

项目成果

Modeling extrinsic noise with stochastic intensity noise: Approximation and its statistical properties

用随机强度噪声建模外在噪声：近似及其统计特性

• 发表时间: 2012
• 作者: Masatoshi Sekine;Hakaru Tamukoh;and Jiang Li;Yoshihiko Hasegawa and Masanori Arita
• 通讯作者: Yoshihiko Hasegawa and Masanori Arita

Programming with Annotated Grammar Estimation, in Chapter 3 of "Genetic Programming-New Approaches and Successful Applications", ISBN 978-953-51-0809-2, InTech

使用带注释的语法估计进行编程，《遗传编程-新方法和成功应用》第 3 章，ISBN 978-953-51-0809-2，InTech

• 发表时间: 2012
• 作者: Kotoko Fujita;Nadav Bergstein;Hakaru Tamukoh and Masatoshi Sekine;Yoshihiko Hasegawa.
• 通讯作者: Yoshihiko Hasegawa.

Period Mismatch Enhances Entrainability in Genetic Oscillator, Joint Conference on Informatics in Biology

周期不匹配增强了遗传振荡器的夹带性，生物学信息学联合会议

• 发表时间: 2012
• 作者: 内田ゆず;荒木健治;米山淳;Yoshihiko Hasegawa and Masanori Arita
• 通讯作者: Yoshihiko Hasegawa and Masanori Arita

Period Mismatch Enhances Entrainability in Genetic Oscillator

周期不匹配增强了遗传振荡器的夹带性

• 发表时间: 2012
• 作者: Yoshifumi Kusunoki;Tetsuzo Tanino;内田ゆず;長谷川禎彦
• 通讯作者: 長谷川禎彦

Langevin Modeling for Extrinsic Fluctuations: Approximation Method and Statistical Properties

外在波动的 Langevin 建模：近似方法和统计特性

• 发表时间: 2012
• 作者: Yoshifumi Kusunoki;Tetsuzo Tanino;内田ゆず;Yoshihiko Hasegawa
• 通讯作者: Yoshihiko Hasegawa