Development of new therapeutic avenues of multiple sclerosis with a focus on glial activation

实验性自身免疫性脑脊髓炎（EAE）是一种多发性硬化（MS）的动物模型，本研究旨在开发多发性硬化的新治疗途径。首先，我们发现口服亚精胺，我们的饮食中的天然成分，降低EAE的严重程度，这表明亚精胺可能适用于MS的治疗。其次，我们揭示了神经和免疫细胞中的RAS-NF. B-TLR 4-ASK 1作为中枢神经系统自身免疫性疾病的有效治疗靶点的新途径。第三，我们发现Dock 8缺陷或过表达都降低了EAE的严重程度，这表明Dock 8表达的调节可能对MS的治疗有效。

Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), was used in our study to develop new therapeutic avenues of multiple sclerosis. Firstly, we found that oral administration of spermidine, a natural component of our diet, reduced the severity of EAE, suggesting that spermidine might be suitable for the treatment of MS. Secondly, we revealed a novel pathway of RAS-NF.B-TLR4-ASK1 in neural and immune cells as a valid therapeutic target for autoimmune disorders in the central nervous system. Thirdly, we found that Dock8 deficiency or overexpression both reduced the severity of EAE, suggesting that modulation of Dock8 expression might be effective for the treatment of MS.