Mechanism of the basal ganglia circuit to regulate motor and motor learning Mechanism of the basal ganglia circuit to regulate motor and motor learning
Mechanism of the basal ganglia circuit to regulate motor and motor learning Mechanism of the basal ganglia circuit to regulate motor and motor learning
批准号:
23700479
负责人:
SANO Hiromi
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
The basal ganglia is supposed to important for motor control. We have applied ‘ optogenetics (the combination of genetics and optics to control cellular excitability)’ to mice to clarify the mechanism of motor control in the pathway of the basal ganglia. Specific excitation in striatal projection neurons in the hemisphere has induced phasic inhibition in the output signal from the basal ganglia, and has induced rotational behavior. These data suggest that phasic response in the output signal is important to regulate motor activity.
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Striatopallidal neurons regulate motor activity through cortically evoked response patterns in the substantia nigra pars reticulata
纹状体苍白球神经元通过黑质网状部皮质诱发反应模式调节运动活动
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Sano H, Chiken S, Hikida T, Kobayashi K, Nambu A]
通讯作者:
Nambu A
生理学研究所ホームページ プレスリリース
国立生理科学研究所主页新闻稿
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Selective activation of cortico-striatal projections by using optogenetics with retrograde gene transfer
利用光遗传学和逆行基因转移选择性激活皮质纹状体投射
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Sano H, Kato S, Chiken S, Kobayashi K, Kobayashi K, Nambu A]
通讯作者:
Nambu A
線条体―淡蒼球投射ニューロンが制御する運動調節機構の解明
阐明纹状体-苍白球投射神经元控制的运动控制机制
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影响因子:
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作者:
[佐野裕美, 知見聡美, 疋田貴俊, 小林和人, 南部 篤]
通讯作者:
南部 篤
日経産業新聞、2013年4月25日、11面、意思に反した手足の動きを抑える神経回路発見
日经产业新闻,2013 年 4 月 25 日,第 11 页,发现神经回路可抑制肢体不自主运动
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共 18 条
A cooperation and practical study on teaching mater ials by which carried was carried out to the Japanese textbook of a high school which Yanagita supervised
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批准号:18K02517
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2018
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负责人:SANO Hiromi
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依托单位:
Physiologocal roles of the basal ganglia on motor control and lerarning.
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批准号:25351002
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:SANO Hiromi
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依托单位:
Analysis of physiological and behavioral roles of the basal ganglia which is regulated by the cortex.
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批准号:20700353
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2008
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负责人:SANO Hiromi
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依托单位:
海外基金