Mechanism of protective effect of Soy isoflavone againist impaired spatial memory in ovariecomized (OVX) mice.

点击翻译按钮获取中文摘要

Soy-isoflavone has been utilized as phytoestrogens to prevention cognitive symptoms found in menopausal women because its biological activities similar to those of estrogens. However, the precise mechanisms underlying its effects remain unknown. In this study, effects of soy-isoflavone on spatial memory were investigated in ovariecomized (OVX) mice. Administration of isoflavone for 4 weeks to OVX mice increased hippocampal levels of IGF-I and prevented the decrease of spatial memory. Immunohistochemical expression of DCX and BrdU suggested an enhancement of neurogenesis in the dentate gyrus of the hippocampus after isoflavone administration. These observations suggest that isoflavone might promote spatial memory through increasing hippocampal IGF-I level and neurogenesis in OVX-mice.