Japanese rice wine (Sake)-derived components has anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis in mice

炎症性肠病（IBD）患者的数量正在增加，饮食习惯的改变是这些增加的因素之一。据报道，几种发酵食品对IBD有改善作用。研究了日本米酒衍生肽对硫酸葡聚糖钠（DSS）诱导小鼠急性结肠炎的抗炎作用。从日本黄酒中提取的部分肽，在少量mg/kg/d浓度下，对结肠炎有改善作用。说明日本清酒提取物对IBD具有较强的治疗作用。

The number of Inflammatory bowel disease (IBD) patients is increasing and the change in eating habit is one of the factor of these increasing. It has been reported that several fermented foods have improving effect of IBD. We determined the anti-inflammatory effect of Japanese rice wine-derived peptide on dextran sulfate sodium (DSS)-induced acute colitis in mice. Some peptide derived from Japanese rice wine showed the colitis improving effect at the concentration of few mg/kg/day. This result indicates that Japanese sake-derived components have a potent of therapeutic agent on IBD.