Molecular mechanisms of the protective effects against memory impairment of rutin

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Various phytochemical constituents have been widely investigated owing to their beneficial effects on health, especially on memory function. We have examined that the effects of some flavonoids (rutin, quercetin and resveratrol) on AMPA receptor trafficking to plasma membrane of hippocampal neurons and neurite outgrowth using PC12 cells. Resveratrol has tended to induce AMPA receptor trafficking to plasma membrane, however rutin and quercetin did not have that effect. On the other hand, rutin and quercetin have tended to induce the neurite outgrowth of PC12 cells, however resveratrol did not effect on neurite outgrowth. Each flavonoid may havespecifically molecular mechanisms of memory function.