Involvement of soluble CD155 in cancer immune escape

点击翻译按钮获取中文摘要

Mouse CD155 has only a membrane-bound form, but human CD155 has also soluble splice isoforms (sCD155) lacking the transmembrane region. Here, we show that cancer patients showed significantly higher concentration of sCD155 in the sera than healthy donors. To analyze the functional role of sCD155 in tumor immunity, we established MethA transfectant expressing sCD155. Mice inoculated with MethA transfectant expressing sCD155 showed increased tumor development and shorter survival, compared with mice inoculated with mock transfectant. These results suggest that sCD155 is involved in cancer immune escape in human.