A novel role of Keap1-Nrf2 signaling pathway underlying the regulation of cancer cells invasion.

Keap1-Nrf2 信号通路在调节癌细胞侵袭中的新作用。

• 批准号: 23701113
• 负责人: ENDO Hitoshi
• 金额: $ 2.75万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701113/
• 关键词: 浸潤; Nrf2; 遺伝子環境相互作用; 酸化ストレス応答

Keap1-Nrf2 is a signaling pathway that strongly influences intrinsic resistant to oxidative stresses and controls adaptive responses to various environmental stressors. Whereas activation of Keap1-Nrf2 pathway contributes the strategy for cancer prevention due to induction of antioxidant and detoxication enzymes in normal cells, Nrf2 activation also promotes survival and development in cancer cells. In the current study, the overexpression of Nrf2 in increasing concentrations resulted in significant enhancement ARE binding sites-mediated MMP promoter activity. Similarly, I have demonstrated using gene knockdown technique of Keap1 that MMP gene was dramatically induced in cancer cells. These results suggested that the activation of Keap1-Nrf2 is not only contributed to cancer cells development but also promotes invasion and metastasis.

Keap 1-Nrf 2是一个信号通路，强烈影响对氧化应激的内在抗性，并控制对各种环境应激的适应性反应。尽管Keap 1-Nrf 2通路的激活由于在正常细胞中诱导抗氧化剂和解毒酶而有助于癌症预防的策略，但Nrf 2激活也促进癌细胞的存活和发展。在目前的研究中，增加浓度的Nrf 2过表达导致ARE结合位点介导的MMP启动子活性显著增强。同样，我已经证明使用Keap 1的基因敲除技术，MMP基因在癌细胞中被显著诱导。这些结果表明，Keap 1-Nrf 2的激活不仅有助于癌细胞的发展，而且还促进了侵袭和转移。

项目成果

プロバイオティクス製剤 MIYAIRI 588はNASH の進展および肝 腫瘍形成を予防する

益生菌配方 MIYAIRI 588 可预防 NASH 进展和肝脏肿瘤形成

• 发表时间: 2013
• 作者: 遠藤整;新岡真希;渡辺哲
• 通讯作者: 渡辺哲

Matrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in Rats

• DOI: 10.1159/000328841
• 发表时间: 2011-01-01
• 期刊: PATHOBIOLOGY
• 影响因子: 5
• 作者: Endo, Hitoshi;Niioka, Maki;Watanabe, Tetsu
• 通讯作者: Watanabe, Tetsu

Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.

• DOI: 10.1371/journal.pone.0063388
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Endo H;Niioka M;Kobayashi N;Tanaka M;Watanabe T
• 通讯作者: Watanabe T

Nrf2活性化剤およびその用途

Nrf2激活剂及其用途

• 发表时间: 2012