NANOCHEMICAL PATTERNING COMBINING SELECTIVE MOLECULAR ASSEMBLY SYSTEMS AND COLLOIDAL LITHOGRAPHY (NANO-SMAP)

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The proposed project "NANO-SMAP" addresses the site-specific spontaneous molecular organization of multifunctional molecules at oxide surfaces to produce geometrically defined surface patterns of biologically functional and specific (recognition) chemistry with feature dimensions of kleiner als 100 nm, ultimately kleiner 10 nm The project combines specific expertise of the project partners in four areas: a) the controlled assembly of colloidal nanosized particles for the production of pre-patterned inorganic substrate surfaces by colloidal lithography; b) the synthesis and characterization of multifunctional alkane phosphates and poly(ethylene glycol)-grafted polyelectrolyte copolymers that selectively assemble on TiO2 and SiO2 surfaces, respectively; c) the production of surface patterns with interactive areas in a non-interactive background based on the selective molecular assembly systems alkane phosphates, PEG-copolymers and supported phospholipid lipid bilayers (SPB, from vesicles); and d) the testing of the resulting surface architectures in model bioassays related to biomaterial and biosensor applications. The project is expected to deliver a novel platform technology for the cost-effective production of biologically relevant nanoscale interface architectures based on a toolbox of molecular and colloidal systems with self-organizing properties.