NANOCHEMICAL PATTERNING COMBINING SELECTIVE MOLECULAR ASSEMBLY SYSTEMS AND COLLOIDAL LITHOGRAPHY (NANO-SMAP)

拟议的项目“Nano-SMAP”解决了多功能分子在氧化物表面特定位置的自发分子组织，以产生生物功能和特定(识别)化学的几何定义的表面图案，特征尺寸为Kleiner ALS 100 nm，最终Kleiner 10 nm。该项目结合了项目合作伙伴在四个领域的特定专业知识：a)胶体纳米颗粒的受控组装，用于通过胶体光刻生产预图案化的无机基材表面；b)分别选择性地组装在二氧化钛和二氧化硅表面的多功能烷基磷酸盐和聚乙二醇接枝聚电解质共聚物的合成和表征；C)基于选择性分子组装体系，在非相互作用的背景中产生具有相互作用区域的表面图案；(D)在与生物材料和生物传感器应用有关的模型生物分析中测试所产生的表面结构。该项目预计将提供一种新的平台技术，用于以具有自组织特性的分子和胶体系统工具箱为基础，以成本效益的方式生产与生物相关的纳米尺度界面结构。

The proposed project "NANO-SMAP" addresses the site-specific spontaneous molecular organization of multifunctional molecules at oxide surfaces to produce geometrically defined surface patterns of biologically functional and specific (recognition) chemistry with feature dimensions of kleiner als 100 nm, ultimately kleiner 10 nm The project combines specific expertise of the project partners in four areas: a) the controlled assembly of colloidal nanosized particles for the production of pre-patterned inorganic substrate surfaces by colloidal lithography; b) the synthesis and characterization of multifunctional alkane phosphates and poly(ethylene glycol)-grafted polyelectrolyte copolymers that selectively assemble on TiO2 and SiO2 surfaces, respectively; c) the production of surface patterns with interactive areas in a non-interactive background based on the selective molecular assembly systems alkane phosphates, PEG-copolymers and supported phospholipid lipid bilayers (SPB, from vesicles); and d) the testing of the resulting surface architectures in model bioassays related to biomaterial and biosensor applications. The project is expected to deliver a novel platform technology for the cost-effective production of biologically relevant nanoscale interface architectures based on a toolbox of molecular and colloidal systems with self-organizing properties.