Regulatory mechanism that regulates ectodomain shedding of HB-EGF by ADAM17

ADAM17 调节 HB-EGF 胞外域脱落的调控机制

• 批准号: 24570212
• 负责人: Iwamoto Ryo
• 金额: $ 3.58万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24570212/
• 关键词: 細胞増殖因子; エクトドメイン・シェディング; 切断酵素; 細胞・組織; シグナル伝達

项目成果

Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice.

有条件地敲除肝脏中与肝素结合的表皮生长因子样生长因子会加速四氯化碳引起的小鼠肝损伤。

• DOI: 10.1111/j.1872-034x.2012.01074.x
• 发表时间: 2012
• 期刊: Hepatol Res
• 影响因子: 4.2
• 作者: Takemura;T.;YoshidaY.;Kiso;S.;Saji;Y.;Ezaki;H.;Hamano;M.;Kizu;T.;Egawa;M.; Chatani;N.;Furuta;K.;Kamada;Y.;Iwamoto;R.;Mekada;E.;Higashiyama;S.;Hayashi;N. and Takehara;T.
• 通讯作者: T.

Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers.

• DOI: 10.1089/mab.2015.0062
• 发表时间: 2016-04
• 期刊: Monoclonal antibodies in immunodiagnosis and immunotherapy
• 作者: Iwamoto R;Takagi M;Akatsuka J;Ono K;Kishi Y;Mekada E
• 通讯作者: Mekada E

Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice.

• DOI: 10.1016/j.bbrc.2013.05.097
• 发表时间: 2013-07
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Takayo Takemura;Y. Yoshida;S. Kiso;Takashi Kizu;Kunimaro Furuta;Hisao Ezaki;Mina Hamano;M. Egawa;Norihiro Chatani;Y. Kamada;Y. Imai;S. Higashiyama;R. Iwamoto;E. Mekada;T. Takehara

心臓弁形成におけるHB-EGF-EGFRシグナルによる細胞増殖制御

心脏瓣膜形成过程中 HB-EGF-EGFR 信号对细胞增殖的控制

• 发表时间: 2013
• 作者: 岩本亮;沼田雄基;目加田英輔
• 通讯作者: 目加田英輔

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