Mechanism regulating cellular proliferation by HB-EGF-ErbB4 signaling and its application

HB-EGF-ErbB4信号调节细胞增殖的机制及其应用

• 批准号: 15K07046
• 负责人: Iwamoto Ryo
• 金额: $ 3.33万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K07046/
• 关键词: 細胞増殖因子; 心臓弁形成; 増殖抑制; 細胞・組織; 形態形成; シグナル伝達; がん増殖

项目成果

Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers.

• DOI: 10.1089/mab.2015.0062
• 发表时间: 2016-04
• 期刊: Monoclonal antibodies in immunodiagnosis and immunotherapy
• 作者: Iwamoto R;Takagi M;Akatsuka J;Ono K;Kishi Y;Mekada E
• 通讯作者: Mekada E

BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study.

• DOI: 10.1186/s12885-017-3071-5
• 发表时间: 2017-01-31
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Miyamoto S;Yotsumoto F;Ueda T;Fukami T;Sanui A;Miyata K;Nam SO;Fukagawa S;Katsuta T;Maehara M;Kondo H;Miyahara D;Shirota K;Yoshizato T;Kuroki M;Nishikawa H;Saku K;Tsuboi Y;Ishitsuka K;Takamatsu Y;Tamura K;Matsunaga A;Hachisuga T;Nishino S;Odawara T;Maeda K;Manabe S;Ishikawa T;Okuno Y;Ohishi M;Hikita T;Mizushima H;Iwamoto R;Mekada E
• 通讯作者: Mekada E

Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF

鉴定对 HB-EGF 具有增强抑制活性的白喉毒素 R 结构域突变体

• DOI: 10.1093/jb/mvu079
• 发表时间: 2015
• 期刊: J Biochem
• 影响因子: 2.7
• 作者: Suzuki K;Mizushima H;Abe H;Iwamoto R;Nakamura H;Mekada E
• 通讯作者: Mekada E

Physiological functions of diphtheria toxin receptor/HB-EGF.

白喉毒素受体/HB-EGF的生理功能。

• 发表时间: 2010
• 作者: Mekada;E.;Iwamoto;R.;岩本 亮;岩本亮;岩本亮;岩本亮
• 通讯作者: 岩本亮

RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity.

RNA适体以高亲和力和特异性结合肝素结合表皮生长因子样生长因子并中和其活性。

• DOI: 10.1016/j.ijge.2017.03.006
• 发表时间: 2017
• 期刊: Int. J. Gerontol.
• 作者: Masaki Yamato;Tetsuo Minamino;yamato masaki;Takashi Matsuzaki;Ryo Araki;Shota Tsuchida;Keiji Okuda;Hai Ying Fu;Shoji Sanada;Hiroshi Asanuma;Yoshihiro Asano;Masanori Asakura;Hiroomi Torii;Kentaro Noi;Hirotsugu Ogi;Ryo Iwamoto;Eisuke Mekada,
• 通讯作者: Eisuke Mekada,