Analysis of the differentiation control factor of leukemia, PRDM16 and physiological inhibitor LR11

白血病分化控制因子PRDM16及生理抑制剂LR11分析

• 批准号: 24591380
• 负责人: SHIMIZU Naomi
• 金额: $ 3.41万
• 依托单位: Toho University (2014)Chiba University (2012-2013)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591380/
• 关键词: LR11; G-CSF; 白血病; 転写因子; プロテアーゼ; WT1; GATA1; GATA2; CD71

项目成果

Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma

• DOI: 10.3109/10428194.2014.880430
• 发表时间: 2014-01
• 期刊: Leukemia & Lymphoma
• 影响因子: 2.6
• 作者: T. Kawaguchi;C. Ohwada;M. Takeuchi;N. Shimizu;E. Sakaida;Y. Takeda;S. Sakai;S. Tsukamoto;Atsuko Yamazaki;Y. Sugita;M. Higashi;K. Fujikawa;K. Matsue;K. Yokote;J. Tamaru;H. Bujo;C. Nakaseko

The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells

LR11 的可溶形式是缺氧诱导、uPAR 介导的未成熟血液细胞粘附的调节剂

• 发表时间: 2013
• 期刊: J Biol Chem
• 影响因子: 4.8
• 作者: Keigo Nishii;Chiaki Nakaseko;Meizi Jiang;Naomi Shimizu;Masahiro Takeuchi;Wolfgang Johann Schneider;and Hideaki Bujo
• 通讯作者: and Hideaki Bujo

Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes.

• DOI: 10.1038/emm.2013.161
• 发表时间: 2014-04-04
• 期刊: EXPERIMENTAL AND MOLECULAR MEDICINE
• 影响因子: 12.8
• 作者: Tsukamoto, Shokichi;Takeuchi, Masahiro;Kawaguchi, Takeharu;Togasaki, Emi;Yamazaki, Atsuko;Sugita, Yasumasa;Muto, Tomoya;Sakai, Shio;Takeda, Yusuke;Ohwada, Chikako;Sakaida, Emiko;Shimizu, Naomi;Nishii, Keigo;Jiang, Meizi;Yokote, Koutaro;Bujo, Hideaki;Nakaseko, Chiaki
• 通讯作者: Nakaseko, Chiaki

Soluble LR11, a novel acute leukemia marker, drastically induces WT1 mRNA expression together with synergic activation of GATAs, and the migration activity.

可溶性 LR11 是一种新型急性白血病标记物，可显着诱导 WT1 mRNA 表达，同时协同激活 GATA 和迁移活性。

• 发表时间: 2012
• 作者: Naomi Shimizu;Chiaki Nakaseko;Masahiro Takeuchi;Chikako Ohwada;Shokichi Tsukamoto;Keigo Nishii;Meiji Jiang;Koutaro Yokote;Isamu Fukamachi;Hideaki Bujo.
• 通讯作者: Hideaki Bujo.

Circulating LR11 is a novel soluble-receptor marker for early-stage clinical conditions in patients with non-Hodgkin's lymphoma.

• DOI: 10.1016/j.cca.2013.12.039
• 发表时间: 2014-03
• 期刊: Clinica chimica acta; international journal of clinical chemistry
• 作者: Kengo Fujimura;Hiroyuki Ebinuma;I. Fukamachi;C. Ohwada;T. Kawaguchi;N. Shimizu;M. Takeuchi;E. Sakaida;M. Jiang;C. Nakaseko;H. Bujo