Analysis of the effects of oxidative stress on DNA methylation and the expression of active DNA demethylation related genes

在这项研究中，我们研究了氧化应激对DNA甲基化和活性DNA去甲基化相关基因表达的影响。本研究结果表明，百草枯诱导的氧化应激增加了DNA去甲基化相关基因Aid的表达。此外，AID的过度表达增加了一些基因的表达。综上所述，这些结果可能表明，氧化应激诱导的AID激活通过DNA去甲基化参与了这些基因的激活。对辅助激活基因启动子甲基化的进一步分析将有助于理解氧化应激对DNA甲基化的影响。

In this study, we investigated the effects of oxidative stress on DNA methylation and the expression of active DNA demethylation related genes. The results of this study showed that paraquat-induced oxidative stress increased the expression of Aid, which is DNA demethylation related gene. Furthermore, over-expression of Aid increased some genes expression. Taken together, these results may suggest that the oxidative stress-induced activation of Aid is involved in those genes activation through the DNA demethylation. Further analysis of promoter methylation of Aid-activated genes will help to understand the effect of oxidative stress on DNA methylation.