Roles of PDIP1, a cofactor for PPARg, in adipocytes

PDIP1（PPARg 的辅助因子）在脂肪细胞中的作用

• 批准号: 24790906
• 负责人: TOMARU Takuya
• 金额: $ 2.66万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790906/
• 关键词: 脂肪細胞; PPARg; 転写共役因子; PDIP1

Obesity increases risk of developing diabetes mellitus, hypertension and dyslipidemia, which finally leads to life-threating disease such as myocardial or cerebral infarction. PPARg has been shown to a master regulator of adiogenesis. We recently identified PDIP1 as a cofactor for PPARg. In this study we made PDIP1-depleted preadipocytes using RNA interfering method, and subjected them to differentiation. PDIP1-depleted adipocytes had less lipid droplets, and lower adipocyte-specific gene expression compared to control cells. These results suggest that PDIP1 is required for adipogenesis. We also compared the gene expression profile of fat tissue of PDIP1-depleted mice and that of wild type mice in genome-wide manner, and identified PDIP1-regulated genes.

肥胖会增加患糖尿病，高血压和血脂异常的风险，最终导致威胁生命的疾病，例如心肌或脑梗塞。 PPARG已显示给拟态的主要调节剂。 我们最近将PDIP1确定为PPARG的辅助因子。 在这项研究中，我们使用RNA干扰方法制作了PDIP1耗尽的前脂肪细胞，并将其进行分化。 与对照细胞相比，PDIP1缺失的脂肪细胞的脂质液滴较少，脂肪细胞特异性基因表达较低。 这些结果表明PDIP1是脂肪形成所必需的。 我们还以全基因组的方式比较了PDIP1缺失小鼠和野生型小鼠的脂肪组织的基因表达谱，并鉴定了PDIP1调节的基因。

项目成果

A case of thyroid storm with a markedly elevated level of circulating soluble interleukin-2 receptor complicated by multiple organ failure and disseminated intravascular coagulation syndrome

• DOI: 10.1507/endocrj.ej14-0073
• 发表时间: 2014-07-01
• 期刊: ENDOCRINE JOURNAL
• 影响因子: 2
• 作者: Shimoda, Yoko;Satoh, Tetsurou;Yamada, Masanobu
• 通讯作者: Yamada, Masanobu

Roles of Helz2, helicase with zinc finger 2, in the maturation of white adipocytes

Helz2（锌指 2 解旋酶）在白色脂肪细胞成熟中的作用

• 发表时间: 2013
• 作者: Takuya Tomaru;Tetsurou Satoh;Satoshi Yoshino;Akiko Katano-Toki;Takahiro Ishizuka;Yasuyo Nakajima;Sumiyasu Ishii;Atsushi Ozawa;Nobuyuki Shibusawa;Koshi Hashimoto;Shuichi Okada;Masanobu Yamada;Masatomo Mori
• 通讯作者: Masatomo Mori

A case of thyroid storm with markedly elevated level of circulating soluble interleukin-2 receptor complicated by multiple organ failure and disseminated intravascular coagulation syndrome

循环可溶性白细胞介素2受体显着升高的甲状腺危象并发多器官功能衰竭和弥散性血管内凝血综合征1例

• 发表时间: 2014
• 期刊: Endocr J
• 影响因子: 2
• 作者: Shimoda Y;Satoh T;Takahashi H;Katano-Toki A;Ozawa A;Tomaru T;Horiguchi K;Kaira K;Nishioka M;Shibusawa N;Hashimoto K;Wakino S;Mori M;Yamada M
• 通讯作者: Yamada M

Protection against high-fat diet induced obesity in Helz2-deficient mice by enhancing hepatic leptin sensitivity, despite central leptin resistance

尽管存在中枢瘦素抵抗，但通过增强肝脏瘦素敏感性来防止 Helz2 缺陷小鼠的高脂肪饮食诱导的肥胖

• 发表时间: 2013
• 作者: Satoshi Yoshino;Tetsurou Satoh;Masanobu Yamada;Takuya Tomaru;Takahiro Ishizuka;Akiko Katano-Toki;Satoru Kakizaki;Hayato Ikota;Munemasa Mori;Koshi Hashimoto;Atsushi Ozawa;Shuichi Okada;Yoichi Nakazato;Takashi Matozaki;Tsutomu Sasaki;Tadahiro
• 通讯作者: Tadahiro

核内受容体転写共役因子PDIP1 は脂肪細胞分化を制御する

核受体转录辅助因子PDIP1调节脂肪细胞分化

• 发表时间: 2013
• 作者: 登丸 琢也;佐藤 哲郎;片野 明子;吉野 聡;石塚 高広;中島 康代;石井 角保;小澤 厚志;渋沢 信行;橋本 貢士;山田 正信;森 昌朋
• 通讯作者: 森 昌朋