The mechanism for secretory IgA antibody induction by TLR3 ligand

TLR3配体诱导分泌型IgA抗体的机制

• 批准号: 24791035
• 负责人: AINAI Akira
• 金额: $ 2.66万
• 依托单位: National Institute of Infectious Diseases
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791035/
• 关键词: 合成二本鎖RNA; アジュバント; 経鼻インフルエンザワクチン; 感染症

Synthetic double-stranded RNAs, TLR3 agonists, are known to be mucosal adjutant to induce virus-specific secretory IgA antibodies in intranasal vaccination against influenza virus infection. On the other hand, TLR7 agonists may be mucosal adjuvants for intranasal vaccination, since influenza viral RNAs are recognized by TLR7 in a natural infection with influenza virus. However, mucosal adjuvant activities of TLR7 agonists were inferior to those of TLR3 agonists.At present, the mechanism for secretory IgA antibody induction by synthetic double-stranded RNAs as mucosal adjuvants is continuously investigated.

合成的双链rna， TLR3激动剂，已知是鼻内接种流感病毒感染疫苗时诱导病毒特异性分泌IgA抗体的粘膜佐剂。另一方面，TLR7激动剂可能是鼻内疫苗接种的粘膜佐剂，因为流感病毒rna在流感病毒的自然感染中被TLR7识别。然而，TLR7激动剂的粘膜佐剂活性不如TLR3激动剂。目前，合成双链rna作为粘膜佐剂诱导分泌IgA抗体的机制仍在不断研究中。

项目成果

Intranasal vaccination with an inactivated whole influenza virus vaccine induces strong antibody responses in serum and nasal mucus of healthy adults.

• DOI: 10.4161/hv.25458
• 发表时间: 2013-09
• 期刊: Human vaccines & immunotherapeutics
• 影响因子: 4.8
• 作者: Ainai A;Tamura S;Suzuki T;van Riet E;Ito R;Odagiri T;Tashiro M;Kurata T;Hasegawa H
• 通讯作者: Hasegawa H

Impact of the quaternary structure of human Secretory-IgA on neutralization potency to Influenza A virus in upper respiratory tract

人分泌型IgA四级结构对上呼吸道甲型流感病毒中和效力的影响

• 发表时间: 2014
• 作者: Suzuki T;Kawaguchi A;Ainai A;Tamura S;Ito R;Tashiro M;Hasegawa H
• 通讯作者: Hasegawa H

感染あるいはワクチン接種歴が経鼻投与型インフルエンザワクチンにより誘導される抗体応答に対して与える影響

感染或疫苗接种史对经鼻注射流感疫苗诱导的抗体反应的影响

• 发表时间: 2012
• 作者: 相内章;池田千将;伊藤良;鈴木忠樹;泉地恭輔;田村愼一;田代眞人;浅沼秀樹;長谷川秀樹
• 通讯作者: 長谷川秀樹

Antibody responses in serum and nasal mucus induced by the intranasal vaccination with a whole-virion inactivated vaccine of A(H5N1) virus in healthy naïve human adults

健康成人鼻内接种 A(H5N1) 病毒全病毒粒子灭活疫苗诱导的血清和鼻粘液中的抗体反应

• 发表时间: 2014
• 作者: Hasegawa H;Ainai A;Suzuki T;van Riet E;Tamura S;Ikeda K;Odagiri T;Tashiro M;Kurata T
• 通讯作者: Kurata T

Antibody responses in serum and nasal mucus induced by the intranasal vaccination with a whole-virion inactivated vaccine of A(H5N1) virus in healthy human adults

健康成人鼻内接种 A(H5N1) 病毒全病毒粒子灭活疫苗诱导的血清和鼻粘液中的抗体反应

• 发表时间: 2013
• 作者: Ainai A;van Riet E;Tamura S;Suzuki T;Kawaguchi A;Ito R;Ikeda K;Senchi K;Asanuma H;Odagiri T;Tashiro M;Kurata T;Hasegawa H
• 通讯作者: Hasegawa H