Experiments for fetal programming by embryonic ultrasound cardiography of mice

点击翻译按钮获取中文摘要

I gave mice in early pregnancy stress such as the drug load and examined an embryonic heart hemodynamic change by performing embryonic ultrasound cardiography. Heart rate , fractional shortening, and cardiac output tended to increase by subcutaneous injecting 0.2 mg/kg of nicotine to a pregnant mice 15-30 minutes after the injection. On the other hand in embryos, carotid artery flow significantly decreased after nicotine injection in comparison with the control group that injected normal saline , and dorsal aorta and umbilical artery flows tended to decrease 15-30 minutes after the injection.This circulation adjustment is a reaction to lead to the blood flow redistribution, and is considered to influence the fetal programming such as an embryonic growth retardation or postnatal developmental disorders.