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Anti-IL-6 antibody attenuates TNF-alpha and cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer

Anti-IL-6 antibody attenuates TNF-alpha and cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
抗 IL-6 抗体可减轻压疮小鼠模型中的 TNF-α 和皮肤缺血再灌注损伤
批准号:
24791142
负责人:
SAITO Yuki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
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英文摘要
In a mouse model of cutaneous ischemia-reperfusion injury, local administration of anti-IL-6 antibody inhibited expression of TNF-alpha and inducible nitric oxide synthase, and reduced cytotoxicity of them. And we checked the safeness about intradermal injection with anti-IL-6 antibody.From that reason, I suggest that anti-IL-6 antibody treatment might prevent the pressure ulcers.
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Clinical significance of organ stiffness in patients with acute decompensated heart failure
  • 批准号:
    20K17164
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
  • 资助金额:
    $0.75万
  • 财政年份:
    2020
  • 负责人:
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  • 依托单位:
Physiological role of the 5HT1AR in the regulation of sleep/wakefulness states
Anti-TNF-alpha antibody attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
  • 批准号:
    22791062
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.58万
  • 财政年份:
    2010
  • 负责人:
    SAITO Yuki
  • 依托单位:
Protection of Surety
  • 批准号:
    18730056
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $1.99万
  • 财政年份:
    2006
  • 负责人:
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  • 依托单位:
海外基金