Anti-IL-6 antibody attenuates TNF-alpha and cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
Anti-IL-6 antibody attenuates TNF-alpha and cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
批准号:
24791142
负责人:
SAITO Yuki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
In a mouse model of cutaneous ischemia-reperfusion injury, local administration of anti-IL-6 antibody inhibited expression of TNF-alpha and inducible nitric oxide synthase, and reduced cytotoxicity of them. And we checked the safeness about intradermal injection with anti-IL-6 antibody.From that reason, I suggest that anti-IL-6 antibody treatment might prevent the pressure ulcers.
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