Development and validation of predictive models for renal function after radical nephrectomy

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Independent predictors of estimated glomerular filtration rate (eGFR) which is an indicator of renal function and chronic kidney disease (CKD) defined as eGFR less than 60 ml/min/1.73 m2 3 years after radical nephrectomy (RN) were identified in patients with kidney cancer. A nomogram for predicting risk of postoperative CKD and a formula for predicting postoperative eGFR were developed in a cohort consisting of non-metastatic kidney cancer patients without preoperative CKD and validated in an external cohort. The predictive models developed and validated in the current study showed satisfactory accuracy for predicting renal function 3 years after RN, and could provide important information to decide treatment for kidney cancer.