Effects of metformin in combination with chemotherapeutic agents on endometrial carcinoma cells

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We assessed the anti-cancer effect of metformin in combination with chemotherapeutic agent (cisplatin) on endometrial cancer cell line. Metformin inhibited endometrial cancer cell proliferation, and potentiated the anti-cancer effect of cisplatin on endometrial cancer cell line. These effects were attenuated under hypoxic condition compared to normoxic condition, though were not antagonized.Administration of metformin with cisplatin does not affect the efficacy of cisplatin, and metformin without cisplatin inhibits cancer cell proliferation. Administration of metformin in combination with cisplatin on the treatment of endometrial cancer probably enhances the therapeutic effects.