Analysis of spiral ligament induction mechanism in the late phase of inner ear development

内耳发育后期螺旋韧带诱导机制分析

• 批准号: 24791810
• 负责人: KOBAYASHI Toshiki
• 金额: $ 2.41万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791810/
• 关键词: 内耳発生; ラセン靭帯

We found that the prospective region of the spiral ligament is reduction in Pax3 gene mutation mice, although neuroepithelial cells and neural crest cells migrate into the intermediate cell region of the developing stria vascularis. Cx26 protein and Tbx18 mRNA expression, spiral ligament induction markers, are reduced in the developing spiral ligament of Pax3 gene mutation mice. These results suggest that Pax3 is related in the maturation of spiral ligament, and the induction signal from the intermediate cells of stria vascularis may be required for it.

我们发现Pax3基因突变小鼠螺旋韧带的前瞻性区域是减少的，尽管神经上皮细胞和神经嵴细胞迁移到发育中的血管纹的中间细胞区域。Pax3基因突变小鼠螺旋韧带发育过程中，螺旋韧带诱导标志物Cx26蛋白和Tbx18 mRNA表达减少。这些结果提示Pax3与螺旋韧带的成熟有关，可能需要血管纹中间细胞的诱导信号。

项目成果

Masataka Okabe. Neural crest cells invade the vesicle derived epithelium

冈部正孝.

• 发表时间: 2012
• 作者: Tomokatsu Udagawa;Norifumi Tatsumi;Toshiki Kobayashi;Masahiro Rikitake;Yuichiro Yaguchi;Hiromi Kojima;Hiroshi Moriyama
• 通讯作者: Hiroshi Moriyama

Neural crest cells migrate into the vesicle derived epithelium

神经嵴细胞迁移到囊泡来源的上皮中

• 发表时间: 2013
• 作者: Tomokatsu Udagawa;Norifumi Tatsumi;Toshiki Kobayashi;Yuichiro Yaguchi;Hiromi Kojima;Hiroshi Moriyama;Masataka Okabe
• 通讯作者: Masataka Okabe