Analysis of melanocytes induction mechanism in the developing stria vascularis by microdissection

显微解剖分析发育中血管纹中黑素细胞的诱导机制

• 批准号: 22791635
• 负责人: KOBAYASHI Toshiki
• 金额: $ 1.58万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791635/
• 关键词: 血管条; メラノサイト; 神経堤細胞; 遊走; 神経堤由来細胞

We found that neural crest cells(NCCs) localize at the intermediate cell region of the developing stria vascularis in Pax3 null mice. However, mRNA expression of melanocyte differentiation marker is remarkably reduced in the developing stria vascularis of Pax3 null mice. These results suggest that Pax3 is not required for NCCs migration into the mouse stria vascularis, but, is responsible for differentiation of NCCs in the mouse stria vascularis.

我们发现，神经嵴细胞（NCCs）定位在中间细胞区的发展血管纹在Pax3基因敲除小鼠。然而，黑素细胞分化标记物的mRNA表达在Pax3敲除小鼠的发育中的血管纹中显著降低。这些结果表明，Pax3不是NCC迁移到小鼠血管纹所必需的，但负责NCC在小鼠血管纹中的分化。

项目成果

Inward rectifier K+ channel Kir4.1 (Kcnj10) is expressed not only in glial cells but also in neurons of the mouse vestibular system

内向整流 K 通道 Kir4.1 (Kcnj10) 不仅在胶质细胞中表达，还在小鼠前庭系统的神经元中表达

• 发表时间: 2011
• 作者: Yao T;Kojima Y;Koyanagi A;Yokoi H;Saito T;Kawano K;Furukawa M;Kusunoki T;Ikeda K;Udagawa T
• 通讯作者: Udagawa T

発生中の内耳へ遊走する神経堤由来細胞の挙動追跡

追踪神经嵴衍生细胞迁移至发育中内耳的行为

• 发表时间: 2011
• 作者: 宇田川友克;辰巳徳史;小林俊樹;小島博己;岡部正隆;森山寛
• 通讯作者: 森山寛