New regulating factor of retinal circulation and establishment of treatment of diabetic retinopathy

我们发现，脂联素是脂肪细胞分泌的一种重要的脂肪细胞因子，主要引起视网膜小动脉内皮依赖性的扩张。此外，在2型糖尿病患者的早期糖尿病视网膜病变中，血浆脂联素浓度与视网膜血流量呈正相关。因为我们先前的临床研究发现，在2型糖尿病患者的早期糖尿病视网膜病变中，RBF是受损的，因此，血清脂联素水平的降低可能会损害2型糖尿病患者的RBF，从而导致视网膜病变的发生。加强脂联素作用的治疗干预可能导致一种新的潜在治疗方法。

We showed that adiponectin, an important adipocytokine secreted by adipocytes, elicits mainly endothelium-dependent dilation of the retinal arterioles. Furthermore, there appears to e a positive relationship between plasma concentration of adiponectin and retinal blood flow in early-stage diabetic retinopathy in patients with type 2 diabetes mellitus. Because, our previous clinical study found that RBF is impaired in early-stage diabetic retinopathy in patients with type 2 diabetes mellitus, it is likely that a decreased serum adiponectin level may impair the RBF, resulting in development of retinopathy, in patients with type 2 diabetes mellitus. therapeutic interventions that enhance the actions of adiponectin may lead to a novel potential treatment.