Comparative twin study in elderly: Relationship between oral status and environmental status

老年人比较双胞胎研究：口腔状况与环境状况的关系

• 批准号: 24792074
• 负责人: MATSUDA Ken-ichi
• 金额: $ 2.66万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792074/
• 关键词: 高齢双生児; 双生児研究; 環境要因; 遺伝要因

The purpose of this study was to detect the heritability of the individual oral health, including tooth loss, ability of chewing, morphologic figures. Morphologic figures such as length or width of the jaw have genetic predisposition. But, loss of teeth is greatly influenced from environmental factors. And the ability of chewing has both aspects of genetic and environmental factors. These results would be important for both dentists and patients to prevent compromised dental condition, and to recognize the limit of the treatment.Second aim was to assess the relationship between number of remaining teeth and arterial sclerosis considering genetic factors. From our study, there was a genetic contribution to the association of them. And even after eliminating such a genetic confounding, there was a significant association of them. Therefore, tooth loss would be considered as an important environmental factor to affect arterial sclerosis.

本研究的目的是探讨个体口腔健康的遗传度，包括牙齿脱落、咀嚼能力、形态特征。下颌的长度或宽度等形态特征具有遗传倾向。但是，牙齿脱落受环境因素的影响很大。咀嚼能力的形成既有遗传因素的影响，也有环境因素的影响。这些结果将是重要的牙医和患者，以防止受损的牙齿条件，并认识到有限的治疗。第二个目的是评估剩余牙齿和动脉硬化症的遗传因素之间的关系。从我们的研究来看，它们之间的联系有一个遗传因素。即使排除了这样的遗传混杂因素，它们之间也有显著的关联。因此，牙齿缺失被认为是影响动脉硬化的重要环境因素。

项目成果

Genetic and environmental influences on oral condition among elder twins

遗传和环境对年长双胞胎口腔状况的影响

• 发表时间: 2013
• 作者: Kurushima Y;Ikebe K;Matsuda K;Enoki K;Ogata S;Yamashita M;Murakami S;Kato K;Hayakawa K;Maeda Y;Osaka Twin Research Group
• 通讯作者: Osaka Twin Research Group

高齢双生児における口腔領域の類似度

老年双胞胎口腔区域的相似性

• 发表时间: 2013
• 作者: Kurushima Y;Ikebe K;Matsuda K;Enoki K;Ogata S;Yamashita M;Murakami S;Kato K;Hayakawa K;Maeda Y;久留島悠子,池邉一典,松田謙一,榎木香織,尾形宗士郎,山下元三,村上伸也,加藤憲司,早川和生,前田芳信
• 通讯作者: 久留島悠子,池邉一典,松田謙一,榎木香織,尾形宗士郎,山下元三,村上伸也,加藤憲司,早川和生,前田芳信