Development of novel treatment on masticatory muscle pain with TMD

TMD治疗咀嚼肌疼痛的新疗法的开发

• 批准号: 24792116
• 负责人: NOMA Noboru
• 金额: $ 2.66万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792116/
• 关键词: 持続的咬筋収縮; ATP; 咬筋痛覚過敏; P2X3受容体; 圧痛閾値; バイオルミネッセンス解析

The mean percentage of FG-labeled P2X3R-positive neurons was significantly increased in TG following successive IL-1beta injections into the MM for 7 days. Successive administration of an IL-1beta receptor-antagonist into the MM attenuated the increase of P2X3-IR cells in the TG. ATP release from MM after 300-g pressure stimulation of MM was also significantly enhanced after CMM. Administration into MM of the selective P2X3,2/3 receptor antagonist A-317491 attenuated the decrement of HWT in CMM rats. A significant increase in HWT was also observed at 30 min after A-317491 (60 µg) injection in IL-1beta-injected rats. These findings suggest that P2X3R expression associated with enhanced IL-1beta expression and ATP release in MM has a possible important role in MM mechanical hyperalgesia after excessive muscular contraction.

在MM内连续注射IL-1β7d后，TG内FG标记的P2X3R阳性神经元的平均百分比显著增加。向MM内连续注射IL-1β受体拮抗剂可减弱TG内P2X3-IR细胞的增加。300 g压力刺激后MM释放的ATP在CMM后也明显增加。MM内注射选择性的P2X3，2/3受体拮抗剂A-317491可减轻CMM大鼠HWT的下降。在注射A-317491(60微克)后30min，IL-1β注射大鼠的HWT也显著增加。这些结果提示，多发性骨髓瘤中P2X3R的表达与IL-1β表达增加和ATP释放有关，可能在肌肉过度收缩后的机械性痛敏中起重要作用。

项目成果

Group cognitive-behavioral intervention for patients with burning mouth syndrome.

• DOI: 10.2334/josnusd.55.17
• 发表时间: 2013-03
• 期刊: Journal of oral science
• 影响因子: 1.9
• 作者: O. Komiyama;H. Nishimura;Y. Makiyama;T. Iida;R. Obara;M. Shinoda;Masayuki Kobayashi;N. Noma;O. Abe;A. De Laat;M. Kawara

非ステロイド性抗炎症薬(NSAIDs)口腔顔面痛の診断と治療 ガイドブック, 日本口腔顔面痛学会 編

非甾体抗炎药（NSAIDs）引起的口面部疼痛的诊断和治疗指南，日本口面部疼痛学会编辑

• 发表时间: 2013
• 作者: Noboru Noma;Yoshiki Imamura;Masamichi Shinoda;Koichi Iwata;Noboru Noma;Noboru Noma;野間 昇;野間 昇
• 通讯作者: 野間 昇

Pain intensity and psychosocial characteristics of patients with burning mouth syndrome and trigeminal neuralgia

• DOI: 10.2334/josnusd.54.321
• 发表时间: 2012-12-01
• 期刊: JOURNAL OF ORAL SCIENCE
• 影响因子: 1.9
• 作者: Komiyama, Osamu;Obara, Ryoko;Kawara, Misao
• 通讯作者: Kawara, Misao

Hemicrania continua in a patient with concomitant dental disease

• DOI: 10.14219/jada.archive.2012.0040
• 发表时间: 2012-10-01
• 期刊: JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
• 影响因子: 3.9
• 作者: Noma, Noboru;Kamo, Hiroshi;Imamura, Yoshiki
• 通讯作者: Imamura, Yoshiki

口腔顔面領域における特発性疼痛(総説)

口面部区域特发性疼痛（综述）

• 发表时间: 2013
• 期刊: ペインクリニック
• 作者: 野間 昇;森蔭 直広;今村 佳樹
• 通讯作者: 今村 佳樹