Relationship between Peri-implant Bone Metabolism and immediate Loading using [18F]NaF-PET Image Analyses

使用 [18F]NaF-PET 图像分析观察种植体周围骨代谢与立即负重之间的关系

• 批准号: 24792130
• 负责人: YAMAMOTO Miou
• 金额: $ 2.75万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792130/
• 关键词: インプラント; 骨代謝; PET

CT and [18F]NaF-PET allowed for a precise estimate of bone metabolism, bone density and trabecular bone structure around the dental implants. Histological deta clearly showed osteogenic reaction around the implants, which related bone metabolism and bone density.Using [18F]NaF-PET, bone metabolism around the implant could be estimated precisely and three-dimensionally. The result suggests the loading effects in early stage on peri-implant bone formation. Comparing with our previous data using Tc99m-MDP bone-scintigraphy, the results of this study showed different manners of bone-metabolism. Those differences might be due to a difference of uptake mechanisms between 2 tracers, namely 18F- and MDP.

CT和[18 F]NaF-PET可以精确估计牙种植体周围的骨代谢、骨密度和骨小梁结构。组织学检查显示种植体周围有明显的成骨反应，与骨代谢和骨密度有关，应用[18 F]NaF-PET能准确、三维地评价种植体周围的骨代谢。结果提示早期加载对种植体周围骨形成有影响。与我们以前用Tc 99 m-MDP骨显像的结果相比，本研究显示了不同的骨代谢方式。这些差异可能是由于两种示踪剂（即18F-和MDP）之间的摄取机制不同所致。

项目成果

Evaluation of Peri-Implant Bone Metabolism with High-resolution-NaF-PET during Mechanical Loading

机械加载过程中使用高分辨率 NaF-PET 评估种植体周围骨代谢

• 发表时间: 2012
• 作者: Matsuo Y;Yamamoto M;Ogawa T;Yokoyama M;Sasaki K.
• 通讯作者: Sasaki K.

Influence of immediate and early loading on bone metabolic activity around dental implants in rat tibiae

即刻和早期负重对大鼠胫骨牙种植体周围骨代谢活性的影响

• DOI: 10.1111/clr.12218
• 发表时间: 2013
• 期刊: Clin Oral Implants Res
• 作者: Yamamoto M;Ogawa T;Yokoyama M;Koyama S;Sasaki K.
• 通讯作者: Sasaki K.

[^<18F>]NaF-PET Image Analyses Peri-implant Bone Metabolism Elictied by Loading

[^<18F>]NaF-PET 图像分析加载引起的种植体周围骨代谢

• 发表时间: 2013
• 作者: Yutaka Matsuo;Miou Yamamoto;Toru Ogawa;Masayoshi Yokoyama;Keiichi Sasaki
• 通讯作者: Keiichi Sasaki

[18F]NaF-PET Image Analyses of Peri-implant Bone Metabolism Elicited by Loading

[18F]NaF-PET 图像分析加载引起的种植体周围骨代谢

• 发表时间: 2013
• 作者: Yutaka Matsuo;Miou Yamamoto;Toru Ogawa;Masayoshi Yokoyama;Keiichi Sasaki
• 通讯作者: Keiichi Sasaki