Histological examination of bone regeneration induced by mesenchymal stem cells: analyses of cell kinetics and bone quality

我们检测了多孔β-磷酸三钙块与骨髓基质细胞混合诱导的骨再生，以阐明骨再生过程中的组织学事件，并在该模型中评估骨质量。新生骨表现为致密骨的组织学特征，由密实排列的胶原纤维组成。新生骨矿化充分。因此，这些结果表明，β-磷酸三钙块与分化的骨髓基质细胞混合具有很高的成骨能力，因此，通过该技术再生的骨具有良好的骨质量。

We examined bone regeneration induce by a porous beta-TCP block mingled with bone marrow stromal cells, in order to clarify histological events during the bone regeneration and to assess bone quality in this model. New bone showed a histological profile of compact bone, and was composed of densely packed collagen fibrils that were orderly arranged. The mineralization of the new bone was sufficient. Thus, these results showed that beta-TCP block mingled with differentiated bone marrow stromal cells had a high osteogenic potential, and therefore, the resultant bone regenerated by this technique appears to possess good bone quality.