Creation of new molecular release systems based on porous coordination polymer capable and metal nanoparticles capable of remotely deliver biologically active molecules under light irradiation

基于多孔配位聚合物和金属纳米粒子创建新的分子释放系统，能够在光照射下远程传递生物活性分子

• 批准号: 24750201
• 负责人: REBOUL Julien
• 金额: $ 2.91万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24750201/
• 关键词: 多孔性金属錯体; 金属ナノ粒子; 分子放出制御; 生体活性分子; 細胞機能評価; 配位高分子; 金属錯体; 多孔体; 有機無機ハイブリッド; 金ナノ結晶; プラズモン

We created new molecular release systems capable of remotely deliver biologically active molecules under light irradiation. To this end, we combined the high storage ability of porous coordination polymers (PCPs), a new class of crystalline materials assembled by organic linkers and inorganic joints at the molecular scale, with the photo-thermal properties of gold nanorods (GNRs) into designed mesoscopic composite materials. These materials consisted in core shell structures composed of a GNR core and an aluminum-based PCP shell. The creation of such mesoscopic structures enabled the implementation of unique motion-induced molecular release, triggered by the highly efficient conversion of optical energy into heat that occurs when the GNRs are irradiated into their plasmon band. Temporal control of the molecular release was demonstrated with anthracene as a guest molecule (priorly immobilized within the pores of the PCP shell) and fluorescent probe by fluorescence spectroscopy.

我们创建了新的分子释放系统，能够在光照射下远程传递生物活性分子。 为此，我们将多孔配位聚合物（PCP）的高存储能力（一种由有机连接体和无机接头在分子尺度组装而成的新型晶体材料）与金纳米棒（GNR）的光热特性结合到设计的介观复合材料中。这些材料采用由 GNR 核和铝基 PCP 壳组成的核壳结构。这种介观结构的创建能够实现独特的运动诱导分子释放，这是由当 GNR 被照射到其等离子体激元带时发生的光能高效转换为热量所触发的。通过荧光光谱法，以蒽作为客体分子（预先固定在 PCP 壳的孔内）和荧光探针，证明了分子释放的时间控制。

项目成果

Construction of porous coordination polymer architectures and composites by a pseudomorphic replacement process

通过假晶置换过程构建多孔配位聚合物结构和复合材料

• 发表时间: 2014
• 作者: Julien Reboul;Masashi Nakahama;Kira Khaletskaya;Shuhei Furukawa;Susumu Kitagawa
• 通讯作者: Susumu Kitagawa

Mesoscopic architectures of porous frameworks fabricated by a coordination-induced replication of a metal oxide parent phase

通过金属氧化物母相的配位诱导复制制备多孔框架的介观结构

• 发表时间: 2012
• 作者: 岡田吉浩;田村真治;今中信人;関;Reboul Julien
• 通讯作者: Reboul Julien

Replication as a method for the construction of shaped porous materials

复制作为成形多孔材料的构造方法

• 发表时间: 2012
• 作者: 関;竹井;早水;都築;齊藤;梅林;Reboul Julien
• 通讯作者: Reboul Julien

Metal‐Organic Framework Materials

• DOI: 10.1002/9780470711385.ch1
• 发表时间: 2010-10
• 期刊: ChemInform
• 作者: C. Kepert