Creation of new molecular release systems based on porous coordination polymer capable and metal nanoparticles capable of remotely deliver biologically active molecules under light irradiation

我们创造了新的分子释放系统，能够在光照射下远程释放生物活性分子。为此，我们将多孔配位聚合物（pcp）的高存储能力与金纳米棒（gnr）的光热特性结合起来，设计出介观复合材料。pcp是一种在分子尺度上由有机连接剂和无机连接剂组装而成的新型晶体材料。这些材料由一个GNR芯和一个铝基PCP壳组成的芯壳结构组成。这种介观结构的创造使得独特的运动诱导分子释放得以实现，当gnr被照射到其等离子体带中时，光能被高效地转化为热量，从而触发了这种释放。以蒽为客体分子（预先固定在PCP外壳的孔内）和荧光探针，通过荧光光谱证明了分子释放的时间控制。

We created new molecular release systems capable of remotely deliver biologically active molecules under light irradiation. To this end, we combined the high storage ability of porous coordination polymers (PCPs), a new class of crystalline materials assembled by organic linkers and inorganic joints at the molecular scale, with the photo-thermal properties of gold nanorods (GNRs) into designed mesoscopic composite materials. These materials consisted in core shell structures composed of a GNR core and an aluminum-based PCP shell. The creation of such mesoscopic structures enabled the implementation of unique motion-induced molecular release, triggered by the highly efficient conversion of optical energy into heat that occurs when the GNRs are irradiated into their plasmon band. Temporal control of the molecular release was demonstrated with anthracene as a guest molecule (priorly immobilized within the pores of the PCP shell) and fluorescent probe by fluorescence spectroscopy.