Universality of circadian behavior under low temperature conditions

低温条件下昼夜节律行为的普遍性

• 批准号: 24770154
• 负责人: ITO HIROSHI
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24770154/
• 关键词: 概日リズム; 温度補償性; シアノバクテリア; KaiC; 生理学

Circadian rhythms are oscillatory phenomena with a 24 hours period. One of the prominent characteristics is temperature compensation of period. We focused on temperature compensation, of which molecular mechanism remain unclear, in terms of bifurcation theory.We had observed circadian rhythms of some organisms under low temperature conditions, and determined the type of bifurcation for the abolishment of circadian rhythms. It had been showed that circadian rhythms of KaiC phosphorylation, fibroblast Arabidopsis and fruits flies were nullified through Hopf bifurcation. Hopf bifurcation under low temperature might relate with temperature compensation because the system near Hopf bifurcation point have low sensitivity to the control parameter.

昼夜节律是具有24小时周期的振荡现象。其突出特点之一是周期温度补偿。根据分叉理论，我们重点研究了温度补偿，其分子机制尚不清楚，我们观察了一些生物体在低温条件下的昼夜节律，并确定了取消昼夜节律的分叉类型。已有研究表明，通过Hopf分叉，KaiC磷酸化、拟南芥成纤维细胞和果蝇的昼夜节律被取消。由于系统在Hopf分岔点附近对控制参数的敏感性较低，低温下的Hopf分叉可能与温度补偿有关。

项目成果

低温下における概日リズムの普遍性時間

低温下昼夜节律的普遍性

• 发表时间: 2012
• 作者: M.Hashimoto;N.Kodera;Y.Tsunaka;M.Oda;M.Tanimoto;T.Ando;K.Morikawa;and S.Tate;伊藤浩史
• 通讯作者: 伊藤浩史

Cyanobacterial circadian clock is nullified under low temperature via Hopf bifurcation

蓝藻生物钟在低温下通过 Hopf 分岔而失效

• 发表时间: 2013
• 作者: 古寺哲幸;内橋貴之;安藤敏夫;伊藤浩史;渡邉力也.;伊藤浩史
• 通讯作者: 伊藤浩史

Regulation of the Cyanobacterial Circadian Clock by Electrochemically Controlled Extracellular Electron Transfer

• DOI: 10.1002/anie.201309560
• 发表时间: 2014-02-17
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Lu, Yue;Nishio, Koichi;Nakanishi, Shuji
• 通讯作者: Nakanishi, Shuji

生物リズムと温度

生物节律和温度

• 发表时间: 2014
• 作者: T. Yamamoto;K. Terao;M. Kawamukai;H. Hamaguchi;and Y. Fujita;伊藤浩史
• 通讯作者: 伊藤浩史

Fluorescence Correlation Spectroscopy to Monitor Kai Protein-based Circadian Oscillations in Real Time

• DOI: 10.1074/jbc.m111.265777
• 发表时间: 2012-01-27
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Goda, Kazuhito;Ito, Hiroshi;Oyama, Tokitaka
• 通讯作者: Oyama, Tokitaka