Identification of autoantibodies in dogs with autoimmune endcrinopathies

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We have developed the method for detecting autoantibodies against proteins isolated from canine adrenocortical gland and other tissues. Autoantibodies against the adrenal proteins were detected in 11 to 33% of dogs with hypoadrenocorticism. In these dogs, hypoadrenocorticism might be related to the autoimmune response. Anti-ovary protein autoantibodies were also detected, which indicated an autoimmune reaction against multiple endocrine tissues. In addition, multiple autoantibodies were found in dogs with hypoadrenocorticism or hypthyroidism. These proteins need to be identified. Results in this study may contribute to diagnosis or research of canine hypoadrenocorticism and hypothyroidism.