Analysis of fatty acid metabolisms and assessment of therapeutic efficacy of PPARs ligands in feline hepatic lipidosis

通过快速减肥在猫中诱导实验性肝硬化，并评估PPARS配体的治疗功效。本研究测定了8个参与脂肪酸代谢的分子的碱基序列，并建立了定量表达的方法。克林贝特给药可增加肝脏脂质蓄积。这一结果警告了在减肥猫中使用克林贝特的危险。

Experimental hepatic lipidosis was induced in cats by rapid weight reduction, and therapeutic efficacy of PPARS ligand was assessed. In this study, base sequences of eight molecules that are involved in fatty acid metabolism were determined, and the quantitative method for their expression was established. Administrations of clinofibrate increased hepatic lipid accumulation. This result warns about the danger of clinofibrate use in weight-reducing cats.