Analysis of fatty acid metabolisms and assessment of therapeutic efficacy of PPARs ligands in feline hepatic lipidosis

猫脂肪肝脂肪酸代谢分析及 PPARs 配体疗效评估

• 批准号: 21780287
• 负责人: NISHII Naohito
• 金额: $ 2.41万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21780287/
• 关键词: 内科; 猫; 肝リピドーシス; PPARs

Experimental hepatic lipidosis was induced in cats by rapid weight reduction, and therapeutic efficacy of PPARS ligand was assessed. In this study, base sequences of eight molecules that are involved in fatty acid metabolism were determined, and the quantitative method for their expression was established. Administrations of clinofibrate increased hepatic lipid accumulation. This result warns about the danger of clinofibrate use in weight-reducing cats.

通过快速减肥在猫中诱导实验性肝硬化，并评估PPARS配体的治疗功效。本研究测定了8个参与脂肪酸代谢的分子的碱基序列，并建立了定量表达的方法。克林贝特给药可增加肝脏脂质蓄积。这一结果警告了在减肥猫中使用克林贝特的危险。

项目成果

脂肪乳剤がネコのインスリン感受性に与える影響

脂肪乳对猫胰岛素敏感性的影响

• 发表时间: 2010
• 作者: 西飯直仁;前田晴香;松鵜彩;日笠善朗
• 通讯作者: 日笠善朗