Development of novel reactions using iron catalyst and silicon reagents

由于铁的价格低廉且安全，开发利用铁催化剂的新型有机反应是有价值的。我们新建立了两种铁催化的反应。(1)铁催化的四氢呋喃和氧代冰片二烯类化合物的官能化，伴随着碳-氧键的开环，可以提供具有药用价值的骨架化合物。(2)虽然硅氧基和甲氧基具有较低的离基能力，但我们发现，利用铁催化剂可以很容易地消除硅氧基和甲氧基，得到各种产物。这种方法对于减少成本和合成步骤是有价值的。

Since iron is inexpensive and safe, the development of the novel organic reactions using iron catalyst is valuable. We newly established two type iron-catalyzed reactions. (1) The iron-catalyzed functionalizations of tetrahydrofurans and oxanorbornadiene derivatives accompanied with the ring-opening of carbon-oxygen bonds can provide the pharmaceutically useful skeltones. (2) Although the siloxy and methoxy groups possess the low abilities as leaving groups, we discovered that the siloxy and methoxy groups could be easily eliminated by the use of iron catalyst to give the various products. This methodology is valuable to enable the reduction of cost and synthetic steps.