Ring-opening functionalizations of heterocycles to highly substituted compounds

杂环化合物的开环功能化反应是高效合成高取代碱性双氢吡喃酮功能材料的重要而又具有挑战性的工作。我们已经建立了C-C或C-N键的形成伴随着开环的四-或二氢呋喃，化学稳定的环系统和稠环衍生物形成不稳定的阳离子中间体，以提供高度官能化的线性和环状产品。本方法适用于制备多用途的生物活性和功能材料。

Ring-opening functionalizations of heterocycles are important and challenging to efficiently synthesize highly-substituted basic skeletones of functional materials. We have established C-C or C-N bond formations accompanying with ring-opening of tetra-or dihydrofurans, thermodynamically stable ring systems and the condensed-ring derivatives forming unstable cation intermediates to afford highly functionalized linear and cyclic products. The present methods are applicable to prepare the versatile bioactive and functional materials.