Basic medicinal chemistry based on behavioral structure-building regulation of protein

在本研究中，我们试图通过基于蛋白质行为结构构建调控的基础药物化学来建立创新的药物开发方法。本研究的目标是折叠调节因子和疾病，旨在缺血/再灌注诱导细胞死亡和丙型肝炎病毒复制。因此，我们成功地开发了对Ca2+诱导的线粒体肿胀有抑制作用的化合物。这些化合物被认为能够抑制缺血/再灌注诱导的细胞死亡。

In this study, we tried to establish innovative drug development methodology by using a basic medicinal chemistry based on behavioral structure-building regulation of protein. A target of this study is folding regulatory factor, and illness to intend for both ischemia/reperfusion induced cell death and hepatitis C virus reproduction. As a result, we succeeded in development of compounds which have inhibitory effect of Ca2+-induced mitochondrial swelling. These compounds were considered to be capable of inhibitor for the ischemia/reperfusion induced cell death.