Regulation of tryptophan metabolism by organic anion transporters

在这项研究中，我进行了药物转运实验，以检查色氨酸代谢物与有机阴离子转运体OAT1和OAT3的相互作用。结果表明，犬尿酸和黄原酸是两种转运蛋白的底物，提示OAT1和OAT3参与了代谢产物的代谢。由于脑组织中犬尿酸水平的异常与几种精神疾病有关，因此与燕麦转运的关系很有趣。通过静脉注射黄尿酸，观察到大鼠排钠的情况。同时给予燕麦片的代表性抑制剂丙磺舒，这种作用消失了。因此，推测燕麦对黄原酸的转运在其利钠作用中起一定作用。

In this study, I performed drug transport experiments to examine interaction of tryptophan metabolites with organic anion transporters OAT1 and OAT3. The results show that kynurenic acid and xanthurenic acid are the substrates of both transporters, and suggest that OAT1 and OAT3 contribute to the disposition of the metabolites. Because abnormal levels of kynurenic acid in the brain link to several psychiatric disorders, relationship with the transport by OATs is interesting.By intravenous infusion of xanthurenic acid to rats, natriuresis was observed. This effect disappeared by simultaneous administration of probenecid, a representative inhibitor of OAT. Accordingly, it is suggested that xanthurenic acid transport by OAT plays a role in its natriuresis.