Molecular mechanism and pathophysiology of nucleophagy induced by cation pump

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In this research, the molecular mechanism and pathophysiology of nucleophagy induced by human ATP13A4 were examined. We found that human ATP13A4 had no ion-transporting function and its N-terminal region was essential for induction of nucleophagy. On the other hand, mouse ATP13A4 had cation-transporting function and did not induce nucleophagy. Related proteins for the ATP13A4-induced nucleophagy were identified by DNA microarray and proteomics. Especially, increased expression levels of proteins involved in proteolytic system and cellular stress response were observed in human ATP13A4-expressing cells.