The role of pain-induced dopamine release within the nucleus accumbens in pain-induced aversion

伏隔核内疼痛引起的多巴胺释放在疼痛引起的厌恶中的作用

• 批准号: 24790245
• 负责人: IDE Soichiro
• 金额: $ 2.83万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790245/
• 关键词: 痛み; 情動; 嫌悪; 側坐核; ドパミン; 不快情動; 抑うつ; 行動薬理

In the present study, we examined the role of pain-induced dopamine release within the nucleus accumbens in pain-induced aversion. A significant increase in the dopamine level was observed after the formalin injection only within the rostral part of the nucleus accumbens shell but not within the caudal part. The conditioned place aversion (CPA) induced by the i.pl. formalin injection was reversed by the microinjection of dopamine D2 antagonist into the rostral part of the nucleus accumbens shell. On the other hand, the microinjection of dopamine D2 agonist into the same region did not induce the CPA.

在本研究中，我们研究的作用，疼痛引起的多巴胺释放的丘脑核内疼痛引起的厌恶。福尔马林注射后，多巴胺水平的显着增加，观察到只有在吻侧部分的核壳，但不是在尾侧部分。条件性位置厌恶（CPA）诱导的i.pl.福尔马林注射可被多巴胺D_2受体拮抗剂注射到延髓背侧核壳的吻侧部所逆转。另一方面，多巴胺D2受体激动剂注射到同一区域没有诱导CPA。

项目成果

痛みによる不快情動生成における背外側分界条床核内神経ペプチド作動性情報伝達の役割

背外侧纹状体核神经肽能信息传递在疼痛引起的不愉快情绪产生中的作用

• 发表时间: 2013
• 作者: 永岡昭吾;浦久保知佳;冨永-吉野恵子;小倉明彦;圓山智嘉史
• 通讯作者: 圓山智嘉史

Effects ofβ-adrenoceptor activation within the bed nucleus of the stria terminalis on food intake and anxiety-like behaviors

终纹床核内β-肾上腺素受体激活对食物摄入和焦虑样行为的影响

• 发表时间: 2012
• 作者: Deyama S;Naka T;Ide S;Nakako T;Hirata M;Majima Y;Takeda H;Yoshioka M;Minami M
• 通讯作者: Minami M

Effects of -adrenoceptor activation within the bed nucleus of the stria terminalis on food intake and anxiety-like behaviors.

的影响

• 发表时间: 2012
• 作者: Deyama S;Naka T;Ide S;Nakako T;Hirata M;Majima Y;Takeda H;Yoshioka M;Minami M
• 通讯作者: Minami M

Opposing effects of corticotropin-releasing factor and neuropepetide Y on neuronal excitability in the dorsolateral bed nucleus of the stira terminalis

促肾上腺皮质激素释放因子和神经肽Y对终搅拌背外侧床核神经元兴奋性的相反作用

• 发表时间: 2013
• 作者: Minami M;Hara T;Ide S;Kaneda K
• 通讯作者: Kaneda K

Serotonergic Modulation of Neuronal Activity in the Nucleus Accumbens Following Repeated Methamphetamine Administration in Rats

大鼠重复服用甲基苯丙胺后伏核神经元活动的血清素调节

• DOI: 10.1254/jphs.13100fp
• 发表时间: 2013
• 期刊: Journal of Pharmacological Sciences
• 影响因子: 3.5
• 作者: Ishihara K;Takahashi N;Komoto N;Yoshikawa C;Fukumoto S;Ide S;Kimura T;OzawaK.
• 通讯作者: OzawaK.