The role of pain-induced dopamine release within the nucleus accumbens in pain-induced aversion

在本研究中，我们研究了疼痛诱导的多巴胺释放在伏隔核中疼痛诱导的厌恶中的作用。注射福尔马林后，多巴胺水平仅在伏隔核喙侧区显著升高，而在尾侧区无显著升高。条件性场所厌恶（CPA）的研究。多巴胺D2拮抗剂微注射伏隔核喙侧壳可逆转福尔马林注射。另一方面，在同一区域注射多巴胺D2激动剂没有诱导CPA。

In the present study, we examined the role of pain-induced dopamine release within the nucleus accumbens in pain-induced aversion. A significant increase in the dopamine level was observed after the formalin injection only within the rostral part of the nucleus accumbens shell but not within the caudal part. The conditioned place aversion (CPA) induced by the i.pl. formalin injection was reversed by the microinjection of dopamine D2 antagonist into the rostral part of the nucleus accumbens shell. On the other hand, the microinjection of dopamine D2 agonist into the same region did not induce the CPA.