The role of opioid neurotransmission in pain-induced aversion

在本研究中，我们研究了阿片样物质内的终纹床核（BNST）在疼痛引起的厌恶的作用。条件性位置厌恶（CPA）由BNST的背外侧部（dlBNST）注射CRF引起的，被逆转的阿片受体激动剂的共同注射。另一方面，dlBNST内注射阿片受体激动剂也能改变痛刺激诱导的伤害性行为。此外，我们发现BNST腹侧部分内的去甲肾上腺素能传递调节食物摄入和焦虑样行为。

In the present study, we examined the role of the opioid within the bed nucleus of the stria terminalis(BNST) in pain-induced aversion. The conditioned place aversion(CPA) induced by intra-dorsolateral part of BNST(dlBNST) injection of CRF was reversed by the co-injection of an opioid agonist. On the other hand, nociceptive behaviors induced by pain stimulus were also changed by intra-dlBNST injection of opioid agonist. Further, we revealed that noradrenergic transmission within the ventral part of BNST regulates food intake and anxiety-like behaviors.