Study for relationship between CAMDI function in cortical lamination and psychiatric disorders

皮质层压CAMDI功能与精神疾病关系的研究

• 批准号: 24790392
• 负责人: FUKUDA Toshifumi
• 金额: $ 2.83万
• 依托单位: Tokyo University of Pharmacy and Life Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790392/
• 关键词: CAMDI; 脳; 発生; ノックアウトマウス; DISC1; 統合失調症; 大脳; 精神疾患

We identified a novel disrupted in schizophrenia 1 (DISC1)-associate protein, named CAMDI. CAMDI knock-down experiment by sh-RNA using in utero electroporation revealed severely impairment of radial migration with disoriented centrosomes. The CAMDI gene knockout mice revealed an abnormal neuronal migration, short dendrite and high spine density at the cerebrum. The cerebrum is known as a brain region related to high-level brain functions such as recognition, learning and memory formation. In addition, abnormality of these functions observed in a brain of psychiatric patients. Thus, we studied a behavior analysis of the CAMDI knockout mice. As a result, the knockout mice showed a hypermobility, hypo-sociability and repetitive behavior. CAMDI gene located a 2q31.2 where is known as a candidate region for autism or related disease. These findings indicate that CAMDI have an important role for normal brain development and might be due to a psychiatric disorder.

我们发现了一种新的精神分裂症1(DISC1)相关蛋白，命名为CAMDI。宫内电穿孔技术对CAMDI基因敲除实验显示，中心体径向迁移受到严重损害。CAMDI基因敲除小鼠的大脑表现出异常的神经元迁移、短的树突和高密度的棘突。大脑被认为是与高级大脑功能相关的大脑区域，如识别、学习和记忆的形成。此外，在精神病患者的大脑中观察到这些功能的异常。因此，我们研究了CAMDI基因敲除小鼠的行为分析。结果，基因敲除的小鼠表现出过度活动、社交能力低下和重复行为。CAMDI基因位于2q31.2，是自闭症或相关疾病的候选区域。这些发现表明，CAMDI对正常的大脑发育有重要作用，可能是由于精神障碍。

项目成果

A mitochondrial ubiquitin ligase MITOL regulates endoplasmic reticulum-mitochondria interaction via mitofusin2

线粒体泛素连接酶 MITOL 通过 mitofusin2 调节内质网-线粒体相互作用

• 发表时间: 2013
• 期刊: Mol. Cell
• 作者: Sugiura;A.
• 通讯作者: A.

CAMDI遺伝子ノックアウトマウスにおける大脳皮質の解析

CAMDI基因敲除小鼠大脑皮层分析

• 发表时间: 2012
• 作者: 山崎紘子;福田敏史;柳 茂
• 通讯作者: 柳 茂

MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin2

• DOI: 10.1016/j.molcel.2013.04.023
• 发表时间: 2013-07-11
• 期刊: MOLECULAR CELL
• 影响因子: 16
• 作者: Sugiura, Ayumu;Nagashima, Shun;Yanagi, Shigeru
• 通讯作者: Yanagi, Shigeru