Study for relationship between CAMDI function in cortical lamination and psychiatric disorders

我们发现了一种新的精神分裂症1 （DISC1）相关蛋白被破坏，命名为CAMDI。用sh-RNA在子宫内电穿孔法敲除CAMDI的实验显示，中心体定向定向的径向迁移严重受损。CAMDI基因敲除小鼠大脑出现异常的神经元迁移、短树突和高棘密度。众所周知，大脑是一个与高级大脑功能相关的大脑区域，如识别、学习和记忆形成。此外，在精神病患者的大脑中也观察到这些功能的异常。因此，我们研究了CAMDI基因敲除小鼠的行为分析。结果，基因敲除小鼠表现出过度活动、低社交性和重复行为。CAMDI基因位于2q31.2位点，是自闭症或相关疾病的候选区域。这些发现表明CAMDI对正常的大脑发育有重要作用，可能是由于精神疾病。

We identified a novel disrupted in schizophrenia 1 (DISC1)-associate protein, named CAMDI. CAMDI knock-down experiment by sh-RNA using in utero electroporation revealed severely impairment of radial migration with disoriented centrosomes. The CAMDI gene knockout mice revealed an abnormal neuronal migration, short dendrite and high spine density at the cerebrum. The cerebrum is known as a brain region related to high-level brain functions such as recognition, learning and memory formation. In addition, abnormality of these functions observed in a brain of psychiatric patients. Thus, we studied a behavior analysis of the CAMDI knockout mice. As a result, the knockout mice showed a hypermobility, hypo-sociability and repetitive behavior. CAMDI gene located a 2q31.2 where is known as a candidate region for autism or related disease. These findings indicate that CAMDI have an important role for normal brain development and might be due to a psychiatric disorder.