CAMDI, a novel DISC1-binding protein, is required for radial migration

这项研究发现了一种新的精神分裂症1 （DISC1）相互作用蛋白，以与肌球蛋白II和DISC1相关的卷曲卷曲蛋白命名为CAMDI。CAMDI敲低显示径向迁移严重受损。有趣的是，CAMDI基因（R828W）的单核苷酸多态性被鉴定出来。此外，R828W在神经元中过表达的小鼠表现出径向迁移受损。我们的研究结果表明，CAMDI在神经元发育过程中是径向所需的。

This study has identified a novel disrupted in schizophrenia 1 (DISC1)-interacting protein, named CAMDI after coiled-coil protein associated with myosin II and DISC1. Knockdown of CAMDI revealed severely impaired radial migration. Interestingly, one single nucleotide polymorphism of the CAMDI gene (R828W) is identified. Furthermore, mice with overexpression of R828W in neurons exhibit an impaired radial migration. Our findings indicate that CAMDI is required for radial during neuronal development.