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Functional analysis of human herpesvirus 6 (HHV-6) glycoprotein Q1 (gQ1)

Functional analysis of human herpesvirus 6 (HHV-6) glycoprotein Q1 (gQ1)
人疱疹病毒 6 (HHV-6) 糖蛋白 Q1 (gQ1) 的功能分析
批准号:
24790442
负责人:
TANG Huamin
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
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英文摘要
Human herpesvirus 6 has been reclassified as two virus species because of the huge different character of its clinical isolates. Here we focused gQ1 genes of HHV-6A and -6B, which have been reported to be important for these viruses' entry. We found that HHV-6B gQ1 could not substitute HHV-6A gQ1 function in the infection context. Furthermore, we found that the N terminal of HHV-6A gQ1 contains the site for the binding of CD46, HHV-6A entry receptor. Furthermore we also identified an amino acid residue required for HHV-6B gQ1 function.
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DOI: 10.1111/1348-0421.12110
发表时间: 2014-01-01
期刊: MICROBIOLOGY AND IMMUNOLOGY
影响因子: 2.6
作者: [Jasirwan, Chyntia, Furusawa, Yoshikazu, Mori, Yasuko]
通讯作者: Mori, Yasuko