Functional analysis of human herpesvirus 6 (HHV-6) glycoprotein Q1 (gQ1)

人类疱疹病毒6型因其临床分离株的巨大差异而被重新分类为两种病毒。本文重点研究了HHV-6A和-6B的gQ 1基因，该基因在HHV-6A和-6B的入侵过程中起重要作用。我们发现HHV-6 B gQ 1在感染背景下不能替代HHV-6A gQ 1功能。此外，我们发现HHV-6A gQ 1的N端含有与HHV-6A进入受体CD 46结合的位点。此外，我们还鉴定了HHV-6 B gQ 1功能所需的氨基酸残基。

Human herpesvirus 6 has been reclassified as two virus species because of the huge different character of its clinical isolates. Here we focused gQ1 genes of HHV-6A and -6B, which have been reported to be important for these viruses' entry. We found that HHV-6B gQ1 could not substitute HHV-6A gQ1 function in the infection context. Furthermore, we found that the N terminal of HHV-6A gQ1 contains the site for the binding of CD46, HHV-6A entry receptor. Furthermore we also identified an amino acid residue required for HHV-6B gQ1 function.