Analysis of immune regulation by dioxin receptor via induction of microRNA
Analysis of immune regulation by dioxin receptor via induction of microRNA
二恶英受体通过 microRNA 诱导的免疫调节分析
批准号：
24790471
负责人：
グェン ナム
金额：
$2.83万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012 至 2013
中文摘要
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英文摘要
We demonstrated that miR-132/miR-212 cluster double knock-out mice are hypersensitive to LPS than WT mice. We showed miR-132/miR-212 cluster is up-regulated in peritoneal macrophages but not in M1 or M2 macrophages in the stimulation of LPS. LPS-induced upregulation of miR-132/miR-212 cluster is suppressed in Ahr knock-out peritoneal macrophages compared to WT cells. We also demonstrated that IL-6 could be a direct target of miR-132/miR-212 cluster. Therefore, Ahr-dependent miR-132/miR-212 negatively regulates LPS-induced IL-6 in peritoneal macrophages.
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会议论文
MiR-132/212 induction is involved in M1 differentiation through an Ahr-dependent mechanism
MiR-132/212 诱导通过 Ahr 依赖性机制参与 M1 分化
MiR-132/212 诱导通过 Ahr 依赖性机制参与 M1 分化
DOI：
--
发表时间：
2012
期刊：
影响因子：
--
作者：
[Gray, E.E., Friend, S., Suzuki, K., Phan, T.G. and Cyster, J.G., Kazuhiro Suzuki, Kazuhiro Suzuki, Nam T. Nguyen et al.]
通讯作者：
Nam T. Nguyen et al.