The regulatory mechanism for interleukin-4 induction in murine basophils
The regulatory mechanism for interleukin-4 induction in murine basophils
批准号:
24790467
负责人:
ODA Akihisa
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Although basophils produce IL-4 in response to IL-3, we discovered that basophils lost IL-3 responsiveness upon activation. PIR-B, the negative regulatory cell curface molecule is involved in the loss of IL-3 responses in activated basophils. In addition, PIR-B also negatively regulates IgG-induced IL-4 production in activated basophils. The inhibitory mechanisms by PIR-B is mediated by ITIM independent manner.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Perivascular mural cells in the postnatal spleen express homeodomain transcription factor Tlx1.
出生后脾脏中的血管周围壁细胞表达同源域转录因子 Tlx1。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Nakahara, R., Oda, A. and Notsu, C., and Goitsuka, R.]
通讯作者:
R.
Homeodomain transcription factor Tlx1 marks a unique population of postnatal spleen mesenchymal cells.
同源域转录因子 Tlx1 标志着出生后脾间充质细胞的独特群体。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Nakahara, R., Kawai, Y., Hirayama, T., Iwakura, Y. and Goitsuka, R]
通讯作者:
R
Mesenchymal progenitor-like cells in the neonatal spleen identified by homeodomain transcription factor Tlx1.
通过同源域转录因子 Tlx1 鉴定新生儿脾中的间充质祖细胞样细胞。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Notsu, C., Oda, A., Nakahara, R. and Goitsuka, R.]
通讯作者:
R.
Developmental regulation of the splenic microenvironment by mesenchymal cells expressing homeodomain transcription factor Tlx1.
表达同源域转录因子 Tlx1 的间充质细胞对脾微环境的发育调节。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Oda, A., Notsu, C., Nakahara, R. and Goitsuka, R.]
通讯作者:
R.
Signaling pathway for interleukin-4 induction in basophils
-
批准号:21890092
-
项目类别:Grant-in-Aid for Research Activity Start-up
-
资助金额:$1.66万
-
财政年份:2009
-
负责人:ODA Akihisa
-
依托单位:
海外基金