Off-label drug evaluation on the newly generated animal model mice for the bipolar disorders

我们之前曾报道，激活素的水平(转化生长因子-β超家族的成员之一)调节突触结构、焦虑相关行为、成人神经发生、晚期LTP和记忆形成。为了阐明激活素信号在大脑中的下游，我们对双相情感障碍依赖激活素的动物模型进行了全面的分析。结果，我们在这些小鼠的大脑中检测到了分子变异和翻译后修饰。此外，我们对这些小鼠的mRNA和miRNA进行了DNA阵列分析，并检测到了波动的分子。下一步，我们将评估标签外药物治疗激活素依赖的动物模型的这些因素，并将化合物重新定义为治疗双相情感障碍的新的潜在疗法。

We previously reported that the level of activin (one member of the TGF-beta superfamily) regulates the synaptic structure, anxiety-related behavior, adult neurogenesis, late-phase LTP and memory formation. To elucidate the downstream of activin signaling in the brain, we performed comprehensive analysis of activin-dependent animal models for bipolar disorders. As a result, we detected molecular variations and posttranslational modification on the brain of these mice. Furthermore, we performed DNA array analyses for mRNA and miRNA on these mice and detected fluctuating molecules. As a next step, we will assess these factors on the treatment of off-label drugs to activin-dependent animal models, and redefine a compound as new potential therapeutics for bipolar disorder.