Development of Closed-loop Implantable Focal Brain Cooling System for non-human primates

局灶性脑冷却对癫痫等多种神经系统疾病具有治疗潜力。在本研究中，我开发了一种植入式冷却装置，可以实现闭环系统。该冷却装置由一个PID控制的，用于冷却大脑的热电芯片和一个用于散热的储存器组成。在猫体内半植入冷却系统表明，该系统可以控制目标温度。然后对该装置进行改进并植入成年猴体内。然而，可以看到冷却性能的限制。基于频率分析的棘波检测方法是应用最优降噪的有效癫痫发作检测方法。未来，我将考虑使用复解调方法和经验模式解压缩来实现分析，其结果可能支持基于植入式局灶性脑冷却装置的热神经调制的技术可行性。

Focal brain cooling has the therapeutic potential to various neurological diseases such as epilepsy. In this study, I developed a implantable cooling device that can be achieved with closed-loop system.The cooling device composed of a PID-controlled, thermoelectric chip for cooling the brain and a reservoir for dissipating heat from the device. Semi-implantation of the cooling system in cats indicated the system could be controlled target temperature. Then the device was modified and implanted in adult monkey. However, a limitation of cooling performance was seen. Spike detection method based on frequency analysis was the effective seizure detection by applying the optimal noise reduction. In the future, I'm considering the implementation of the analysis using the complex demodulation method and empirical mode decompression.The results potentially supported the technical feasibility of thermal neuromodulation based on the implantable focal brain cooling device.