Development of Closed-loop Implantable Focal Brain Cooling System for non-human primates

局灶性脑冷却对癫痫等多种神经系统疾病具有治疗潜力。在这项研究中，我开发了一种可植入的冷却装置，可以通过闭环系统来实现。该冷却装置由用于冷却大脑的pid控制的热电芯片和用于从该装置散热的储热器组成。该冷却系统在猫体内的半植入试验表明，该系统可以控制目标温度。然后对该装置进行改造并植入成年猴子体内。然而，在冷却性能上存在一定的局限性。基于频率分析的尖峰检测方法是应用最优降噪的有效检测方法。在未来，我正在考虑使用复解调方法和经验模式解压缩来实现分析。研究结果为基于植入式局灶脑冷却装置的热神经调节技术提供了可行性支持。

Focal brain cooling has the therapeutic potential to various neurological diseases such as epilepsy. In this study, I developed a implantable cooling device that can be achieved with closed-loop system.The cooling device composed of a PID-controlled, thermoelectric chip for cooling the brain and a reservoir for dissipating heat from the device. Semi-implantation of the cooling system in cats indicated the system could be controlled target temperature. Then the device was modified and implanted in adult monkey. However, a limitation of cooling performance was seen. Spike detection method based on frequency analysis was the effective seizure detection by applying the optimal noise reduction. In the future, I'm considering the implementation of the analysis using the complex demodulation method and empirical mode decompression.The results potentially supported the technical feasibility of thermal neuromodulation based on the implantable focal brain cooling device.