Elucidation of the pathogenic mechanism of, and construction of therapeutic strategy for, Neurofibromatosis type 1-associated tumors via TCTP

通过TCTP阐明1型神经纤维瘤病相关肿瘤的发病机制并构建治疗策略

• 批准号: 24700981
• 负责人: KOBAYASHI Daiki
• 金额: $ 2.83万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700981/
• 关键词: 神経線維腫; NF1; TCTP; Neurofibromin; プロテオミクス

Neurofibromatosis type-1 (NF1) is an inherited disorder that presents various pathological conditions including benign neurofibromas and malignant tumors. Due to the lack of information on the molecular mechanism of NF1-associated tumor pathogenesis or biomarkers/therapeutic targets, a radical treatment for NF1 tumors has not been established. In this study, we evaluated whether the novel NF1-associated protein, translationally controlled tumor protein (TCTP), could be a novel biomarker and therapeutic target for NF1-associated tumors. We found that TCTP expression level correlated with their malignancy and contributes to NF1-associated tumor cell growth. Collective to our findings, it is expected that a diagnostic method and therapeutic strategies targeting TCTP for NF1-associated tumors has been developed.

1型神经纤维瘤病（NF 1）是一种遗传性疾病，表现为各种病理状态，包括良性神经纤维瘤和恶性肿瘤。由于缺乏关于NF 1相关肿瘤发病机制或生物标志物/治疗靶点的分子机制的信息，尚未建立NF 1肿瘤的根治性治疗。在这项研究中，我们评估了新的NF 1相关蛋白，免疫控制肿瘤蛋白（TCTP），是否可以成为NF 1相关肿瘤的新生物标志物和治疗靶点。我们发现TCTP表达水平与其恶性程度相关，并有助于NF 1相关的肿瘤细胞生长。集体对我们的研究结果，它是预期的诊断方法和治疗策略靶向TCTP的NF 1相关肿瘤已被开发。

项目成果

腫瘍細胞内ビメンチンの翻訳後就職およびフラグメント化とその機能解析

肿瘤细胞中波形蛋白的翻译后募集和片段化及其功能分析

• 发表时间: 2012
• 作者: 山口浩;小林大樹;荒木令江
• 通讯作者: 荒木令江

An Integrated Proteomics for Extracting Molecular Target of Malignant Gliomas.

用于提取恶性胶质瘤分子靶标的集成蛋白质组学。

• 发表时间: 2013
• 作者: Norie Araki;Takashi Morikawa;Souhei Mizuguchi;Daiki Kobayashi;Akiko Niibori Nambu;Uichi Midorikawa;Mio Hirayama;Masayo morifuji Wilson;Sin Kawano;Hideo Nakamura;Junichi Kuratsu.
• 通讯作者: Junichi Kuratsu.

Integrated Proteomics Identified Novel Activation of Dynein IC2-GR-COX-1 Signaling by Suppression of NF1 Tumor Suppressor Gene Product, Neurofibromin, in Neuronal Cells..

综合蛋白质组学通过抑制神经元细胞中的 NF1 肿瘤抑制基因产物神经纤维蛋白，确定了动力蛋白 IC2-GR-COX-1 信号传导的新激活。

• 发表时间: 2013
• 作者: Daiki Kobayashi;Mio Hirayama;Souhei Mizuguchi Takashi Morikawa;Megumi Nagayama;Uichi Midorikawa;Masayo Wilbu-Niibori;Akiyasu Yoshizawa C.;Shin Kawano;Norie Araki.
• 通讯作者: Norie Araki.

Analysis of abnormal cellular signals via silencing of NF1 tumor suppressor protein in neuronal cells by integrated proteomics

通过整合蛋白质组学分析神经元细胞中 NF1 肿瘤抑制蛋白沉默引起的异常细胞信号

• 发表时间: 2012
• 作者: Hirayama M;Kobayashi D;Morikawa T;Nagayama M;Mizuguchi S;Araki N.
• 通讯作者: Araki N.

Integrated Proteomics Identified Translationally Controlled Tumor Protein as aBiological Target for Neurofibroma andMalignant Peripheral Nerve Sheath Tumors

综合蛋白质组学鉴定翻译控制的肿瘤蛋白作为神经纤维瘤和恶性周围神经鞘肿瘤的生物靶标

• 发表时间: 2012
• 作者: Kobayashi D;Hirayama M;Komohara Y ,Mizuguchi S;Wilson-morifuji M;Ihn h,Takeya M;Kuramochi A;Araki N.
• 通讯作者: Araki N.