Elucidation of the pathogenic mechanism of, and construction of therapeutic strategy for, Neurofibromatosis type 1-associated tumors via TCTP

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Neurofibromatosis type-1 (NF1) is an inherited disorder that presents various pathological conditions including benign neurofibromas and malignant tumors. Due to the lack of information on the molecular mechanism of NF1-associated tumor pathogenesis or biomarkers/therapeutic targets, a radical treatment for NF1 tumors has not been established. In this study, we evaluated whether the novel NF1-associated protein, translationally controlled tumor protein (TCTP), could be a novel biomarker and therapeutic target for NF1-associated tumors. We found that TCTP expression level correlated with their malignancy and contributes to NF1-associated tumor cell growth. Collective to our findings, it is expected that a diagnostic method and therapeutic strategies targeting TCTP for NF1-associated tumors has been developed.