Radiobiological effect induced by laser-plasma soft x-ray microbeam

激光等离子体软X射线微束诱导的放射生物学效应

• 批准号: 24710096
• 负责人: NISHIKINO Masaharu
• 金额: $ 2.83万
• 依托单位: Japan Atomic Energy Agency
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24710096/
• 关键词: レーザープラズマＸ線; 軟Ｘ線レーザー; 放射線生物影響; マイクロビーム; レーザープラズマX線; フレネルゾーンプレート

Techniques for generating high energy bright short-pulse x-rays have been developed with utilizing intense ultrashort laser pulses. X-ray focusing optics has enabled focused x-ray beams of micron spot size in soft x-ray regions. The short duration of laser produced plasma source could be a new source in contrast to conventional x-ray sources in investigating the mechanism of the radiation effect on biological cells. We investigated whether the soft X-ray laser induces the DNA double strand breaks (DSB) and single strand breaks (SSB) in living cell or not. The appearance of DSB induced by soft X-ray laser was significantly different in that induced by a conventional high energy X-ray source. We also demonstrated an efficient extreme ultraviolet source for an X-ray microscopy technique, and developed a grazing angle incident reflection type soft-X-ray microscope using a Fresnel zone plate.

通过使用强烈的超短激光脉冲，已经开发出产生高能明亮短脉冲X射线的技术。 X射线焦点光学元件使柔软的X射线区域中的Micron斑点大小的聚焦X射线梁。与传统的X射线源一起研究辐射对生物细胞的机理，激光产生的血浆源的短持续时间可能是一个新来源。我们研究了软X射线激光是否在活细胞中诱导DNA双链断裂（DSB）和单链断裂（SSB）。在传统的高能X射线源引起的X射线激光器引起的DSB的出现显着差异。我们还为X射线显微镜技术展示了有效的极端紫外线源，并使用菲涅耳区板开发了放牧角入射反射型软X射线显微镜。

项目成果

Observation of the surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique

时间分辨软X射线成像技术观察飞秒激光烧蚀表面动力学

• 发表时间: 2013
• 作者: 大下英敏;石綿将邦;岩瀬和也;武藤豪;佐藤節夫;瀬谷智洋;坂口将尊;大友季哉;池田一貴;金子直勝;鈴谷賢太郎;藤崎布美佳;Masaharu Nishikino
• 通讯作者: Masaharu Nishikino

Development of soft x-ray microscopy using Fresnel zone plate for observation of laser-induced surface dynamics

开发使用菲涅耳波带板观察激光诱导表面动力学的软 X 射线显微镜

• 发表时间: 2013
• 期刊: Springer proceedings in Physics
• 作者: M. Nishikino;M. Baba;T. Suemoto;N. Hasegawa;M. Ishino;T. Kaihori;T. Kawachi and M. Yamagiwa
• 通讯作者: T. Kawachi and M. Yamagiwa

Observation of the nano-scale surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique

通过时间分辨软X射线成像技术观察飞秒激光烧蚀的纳米级表面动力学

• 发表时间: 2013
• 期刊: Proceedings of SPIE
• 作者: 大下英敏;石綿将邦;岩瀬和也;武藤豪;佐藤節夫;瀬谷智洋;坂口将尊;大友季哉;池田一貴;金子直勝;鈴谷賢太郎;藤崎布美佳;M. Nishikino et al.(他12名)
• 通讯作者: M. Nishikino et al.(他12名)

プラズマＸ線レーザーの発生と物質アブレーション

等离子体 X 射线激光的产生和材料烧蚀

• 作者: Che Y.;Zinchenko A.;Murata S.;Masaharu Nishikino;錦野将元
• 通讯作者: 錦野将元

Development of soft x-ray microscopy using Fresnel zone plate for ibservation of laser-induced surface dynamics

开发使用菲涅尔波带板观察激光诱导表面动力学的软 X 射线显微镜

• 发表时间: 2012
• 作者: 大下英敏;石綿将邦;岩瀬和也;武藤豪;佐藤節夫;瀬谷智洋;坂口将尊;大友季哉;池田一貴;金子直勝;鈴谷賢太郎;藤崎布美佳;錦野将元;Masaharu Nishikino
• 通讯作者: Masaharu Nishikino