Radiobiological effect induced by laser-plasma soft x-ray microbeam

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Techniques for generating high energy bright short-pulse x-rays have been developed with utilizing intense ultrashort laser pulses. X-ray focusing optics has enabled focused x-ray beams of micron spot size in soft x-ray regions. The short duration of laser produced plasma source could be a new source in contrast to conventional x-ray sources in investigating the mechanism of the radiation effect on biological cells. We investigated whether the soft X-ray laser induces the DNA double strand breaks (DSB) and single strand breaks (SSB) in living cell or not. The appearance of DSB induced by soft X-ray laser was significantly different in that induced by a conventional high energy X-ray source. We also demonstrated an efficient extreme ultraviolet source for an X-ray microscopy technique, and developed a grazing angle incident reflection type soft-X-ray microscope using a Fresnel zone plate.