Radiobiological effect induced by laser-plasma soft x-ray microbeam

激光等离子体软X射线微束诱导的放射生物学效应

• 批准号: 24710096
• 负责人: NISHIKINO Masaharu
• 金额: $ 2.83万
• 依托单位: Japan Atomic Energy Agency
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24710096/
• 关键词: レーザープラズマＸ線; 軟Ｘ線レーザー; 放射線生物影響; マイクロビーム; レーザープラズマX線; フレネルゾーンプレート

Techniques for generating high energy bright short-pulse x-rays have been developed with utilizing intense ultrashort laser pulses. X-ray focusing optics has enabled focused x-ray beams of micron spot size in soft x-ray regions. The short duration of laser produced plasma source could be a new source in contrast to conventional x-ray sources in investigating the mechanism of the radiation effect on biological cells. We investigated whether the soft X-ray laser induces the DNA double strand breaks (DSB) and single strand breaks (SSB) in living cell or not. The appearance of DSB induced by soft X-ray laser was significantly different in that induced by a conventional high energy X-ray source. We also demonstrated an efficient extreme ultraviolet source for an X-ray microscopy technique, and developed a grazing angle incident reflection type soft-X-ray microscope using a Fresnel zone plate.

利用强超短激光脉冲产生高能量明亮短脉冲x射线的技术已经得到发展。X射线聚焦光学器件使得能够在软X射线区域中聚焦微米光斑尺寸的X射线束。激光等离子体源的短持续时间可以作为研究生物细胞辐射效应机理的一种新的X射线源。本文研究了软X射线激光是否诱发活细胞DNA双链断裂和单链断裂。由软X射线激光引起的DSB的出现与由常规高能X射线源引起的DSB的出现显著不同。我们还展示了一个有效的极紫外光源的X射线显微镜技术，并开发了一个掠角入射反射型软X射线显微镜使用菲涅耳波带片。

项目成果

Observation of the surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique

时间分辨软X射线成像技术观察飞秒激光烧蚀表面动力学

• 发表时间: 2013
• 作者: 大下英敏;石綿将邦;岩瀬和也;武藤豪;佐藤節夫;瀬谷智洋;坂口将尊;大友季哉;池田一貴;金子直勝;鈴谷賢太郎;藤崎布美佳;Masaharu Nishikino
• 通讯作者: Masaharu Nishikino

Development of soft x-ray microscopy using Fresnel zone plate for observation of laser-induced surface dynamics

开发使用菲涅耳波带板观察激光诱导表面动力学的软 X 射线显微镜

• 发表时间: 2013
• 期刊: Springer proceedings in Physics
• 作者: M. Nishikino;M. Baba;T. Suemoto;N. Hasegawa;M. Ishino;T. Kaihori;T. Kawachi and M. Yamagiwa
• 通讯作者: T. Kawachi and M. Yamagiwa

Observation of the nano-scale surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique

通过时间分辨软X射线成像技术观察飞秒激光烧蚀的纳米级表面动力学

• 发表时间: 2013
• 期刊: Proceedings of SPIE
• 作者: 大下英敏;石綿将邦;岩瀬和也;武藤豪;佐藤節夫;瀬谷智洋;坂口将尊;大友季哉;池田一貴;金子直勝;鈴谷賢太郎;藤崎布美佳;M. Nishikino et al.(他12名)
• 通讯作者: M. Nishikino et al.(他12名)

Development of soft x-ray microscopy using Fresnel zone plate for ibservation of laser-induced surface dynamics

开发使用菲涅尔波带板观察激光诱导表面动力学的软 X 射线显微镜

• 发表时间: 2012
• 作者: 大下英敏;石綿将邦;岩瀬和也;武藤豪;佐藤節夫;瀬谷智洋;坂口将尊;大友季哉;池田一貴;金子直勝;鈴谷賢太郎;藤崎布美佳;錦野将元;Masaharu Nishikino
• 通讯作者: Masaharu Nishikino

プラズマＸ線レーザーの発生と物質アブレーション

等离子体 X 射线激光的产生和材料烧蚀

• 作者: Che Y.;Zinchenko A.;Murata S.;Masaharu Nishikino;錦野将元
• 通讯作者: 錦野将元