Thyroid Hormone Receptor Corepressors: Requirements and Selectivity for Histone Modifications Cell Culture

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Thyroid hormone (T3) is an important regulator of neuronal differentiation and maturation. The receptor for thyroid hormone (TR) is a ligand regulated transcription factor mediating both gene repression and activation. A number of different corepressors have been described to interact with TR. Corepressors bind either in a hormone-sensitive, hormone-independent or hormone-dependent manner to TR. However, it is not understood which biological functions individual corepressors play in the context of TR-mediat ed gene repression and activation as well as for TR-mediated neuronal differentiation and maturation. This project analyses the selectivity and specificity of corepressors in the context of chromatin through histone modifications (acetylation, methylation, phosphorylation and ubiquitinylation) of TR target genes as well as the impact of corepressors on neuronal differentiation and maturation.