Study on the mechanism underlying the centrosome amplification induced by DNA repair abnormality in cancer

癌症DNA修复异常引起中心体扩增的机制研究

• 批准号: 25460476
• 负责人: Shinmura Kazuya
• 金额: $ 3.33万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460476/
• 关键词: Centrosome amplification; DNA repair; SASS6; SGOL1; NEIL; MUTYH; STK15; 中心体; WDR62; DNAグリコシラーゼ; 中心体過剰複製; ラギング染色体; 染色体不安定性; 予後不良因子; TDG; DNA修復酵素遺伝子; DNA付加体; MUTYH関連ポリポーシス; 遺伝子増幅

项目成果

Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.

• DOI: 10.1155/2016/1546392
• 发表时间: 2016
• 期刊: Oxidative medicine and cellular longevity
• 作者: Shinmura K;Kato H;Kawanishi Y;Igarashi H;Goto M;Tao H;Inoue Y;Nakamura S;Misawa K;Mineta H;Sugimura H
• 通讯作者: Sugimura H

PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer

• DOI: 10.1007/s11033-014-3546-2
• 发表时间: 2014-10-01
• 期刊: MOLECULAR BIOLOGY REPORTS
• 影响因子: 2.8
• 作者: Shinmura, Kazuya;Kurabe, Nobuya;Sugimura, Haruhiko
• 通讯作者: Sugimura, Haruhiko

Functional Evaluation of Nine Missense-Type Variants of the Human DNA Glycosylase Enzyme MUTYH in the Japanese Population.

日本人群中人类 DNA 糖基化酶 MUTYH 的九种错义型变体的功能评估。

• DOI: 10.1002/humu.22949
• 发表时间: 2016
• 期刊: Hum Mutat.
• 作者: Shinmura K;Kato H;Goto M;Yamada H;Tao H;Nakamura S;Sugimura H.
• 通讯作者: Sugimura H.

SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer.

• DOI: 10.3892/or.2015.4014
• 发表时间: 2015-08
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: K. Shinmura;Hisami Kato;Y. Kawanishi;K. Nagura;T. Kamo;Y. Okubo;Y. Inoue;Nobuya Kurabe;Chunping Du-C

SASS6高発現は大腸癌のM期染色体異常と患者予後不良と関連性を示す

SASS6 高表达与结直肠癌 M 期染色体异常和患者预后不良相关

• 发表时间: 2015
• 作者: 新村和也;加藤寿美;川西祐一;加茂隆春;井上裕介;倉部誠也;杜春平;倉地清隆;中村利夫;椙村春彦.
• 通讯作者: 椙村春彦.