Differential gene expression of mesenchymal stem cells derived from bone-marrow and synovial-tissues

骨髓和滑膜组织来源的间充质干细胞的差异基因表达

• 批准号: 25462362
• 负责人: EZURA Yoichi
• 金额: $ 3.24万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462362/
• 关键词: 間葉系幹細胞; 組織間質細胞; 間葉系前駆細胞; 軟骨細胞分化能; 滑膜由来細胞; 骨髄由来細胞; 半月板由来細胞; 遺伝子発現

项目成果

Interleukin-1β suppresses expression of osteoblastic genes as well as the regulators of ecto-nucleotides and pyrophosphate that negatively regulate bio-mineralization in mouse bone marrow stromal cells

Interleukin-1β 抑制成骨细胞基因以及外核苷酸和焦磷酸调节剂的表达，从而负向调节小鼠骨髓基质细胞的生物矿化

• 发表时间: 2015
• 作者: Ezura Y;Hatta A;Lin Xin;Yayoi Izu;Hayata T;Noda M.
• 通讯作者: Noda M.

Identification of differentially expressed genes in mesenchymal stem cells derived from synovium, meniscus and ligament.

滑膜、半月板和韧带来源的间充质干细胞差异表达基因的鉴定。

• 发表时间: 2013
• 作者: Ezura Y;Hayata T;Notomi T;Noda M.
• 通讯作者: Noda M.

Interleukin-1β Suppresses the Transporter Genes Ank and Ent1 Expression in Stromal Progenitor Cells Retaining Mineralization

• DOI: 10.1007/s00223-016-0139-1
• 发表时间: 2016-08-01
• 期刊: CALCIFIED TISSUE INTERNATIONAL
• 影响因子: 4.2
• 作者: Ezura, Yoichi;Lin, Xin;Noda, Masaki
• 通讯作者: Noda, Masaki

Genes significantly highly expressed in synovium derived stromal cells than in bone marrow derived cells are conserved both in mouse and human, and may contribute to higher potential for chondrogenic differentiation.

在滑膜来源的基质细胞中比在骨髓来源的细胞中显着高表达的基因在小鼠和人类中都是保守的，并且可能有助于更高的软骨形成分化潜力。

• 发表时间: 2013
• 作者: Ezura Y;Hayata T;Notomi T;Sekiya I;Noda M.
• 通讯作者: Noda M.