Exploration of mechanisms underlying organ-specific aberrant VEGF signaling in sepsis and development of innovative therapeutic approaches based on microcirculation

探索脓毒症中器官特异性异常 VEGF 信号转导机制，并开发基于微循环的创新治疗方法

• 批准号: 25462812
• 负责人: JESMIN Subrina
• 金额: $ 3.16万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462812/
• 关键词: 敗血症; 外科系臨床医学; 救急医学; 集中治療学; 医学

项目成果

ＬＰSＳ誘発性敗血症性腎障害へのβ1遮断薬の影響―腎組織の炎症系とEndothelin系からの考察―

β1阻滞剂对LPSS诱导的脓毒症肾损伤的影响 - 从肾组织炎症系统和内皮素系统考虑 -

• 发表时间: 2014
• 作者: 1.山口直人;Jesmin S;小倉吉保;下條信威;山木万里郎;鹿野直人;大瀬寛高;水谷太郎.
• 通讯作者: 水谷太郎.

Effects of repeated closed vs. open endotracheal suctioning during mechanical ventilation on the pulmonary and circulatory levels of endothelin-1 in a lavage induced surfactant depleted rabbit ARDS model

机械通气期间重复封闭与开放气管内抽吸对灌洗诱导的表面活性剂耗尽兔 ARDS 模型中肺和循环内皮素-1 水平的影响

• 发表时间: 2013
• 作者: Sakuramoto H;Jesmin S;Shimojo N;Kamiyama J;Islam M;Khatun T;Kawano S;Mizutani T
• 通讯作者: Mizutani T

Repeated open endotracheal suctioning causes gradual desaturation but does not exacerbate lung injury compared to closed endotracheal suctioning in a rabbit model of ARDS.

• DOI: 10.1186/1471-2253-13-47
• 发表时间: 2013-12-05
• 期刊: BMC anesthesiology
• 影响因子: 2.2
• 作者: Sakuramoto H;Shimojo N;Jesmin S;Unoki T;Kamiyama J;Oki M;Miya K;Kawano S;Mizutani T
• 通讯作者: Mizutani T

Effects of landiolol hydrochloride, an ultra-short-acting β-blocker, on cardiac endothelin system in a rat model of endotoxemia: a possible relevance with cardiac functional compensatory events at the early phase of sepsis

盐酸兰地洛尔（一种超短效β受体阻滞剂）对内毒素血症大鼠模型心脏内皮素系统的影响：与脓毒症早期心脏功能代偿事件的可能相关性

• 发表时间: 2013
• 作者: Seki Y;Jesmin S;Shimojo N;Islam M;Khatun T;Sakuramoto H;Kamiyama J;Hagiya K;Kawano S;Mizutani T
• 通讯作者: Mizutani T

Blood pressure independent downregulation of plasma endothelin-1 levels in a lavage-induced surfactant depleted rabbit ARDS model: Effects of various respiratory maneuvers on endothelin-1 levels

在灌洗诱导的表面活性剂耗尽的兔 ARDS 模型中，血浆内皮素 1 水平的血压独立下调：各种呼吸操作对内皮素 1 水平的影响

• 发表时间: 2013
• 作者: Kamiyama J;Jesmin S;Sakuramoto H;Islam M;Khatun T;Shimojo N;Kawano S;Mizutani T
• 通讯作者: Mizutani T